| Name | Nerve growth factor |
|---|---|
| Synonyms | Beta NGF; Beta nerve growth factor; Beta nerve growth factor precursor; HSAN 5; HSAN5; NGF; NGFB; Nerve growth factor… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17647100 | Takadera T, Ohyashiki T: Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. Cell Mol Neurobiol. 2007 Sep;27(6):783-90. Epub 2007 Jul 24. In addition, nerve growth factor and cycloheximide, a protein synthesis inhibitor, completely blocked cell death. |
32(0,1,1,2) | Details |
| 15870071 | Vargas MR, Pehar M, Cassina P, Martinez-Palma L, Thompson JA, Beckman JS, Barbeito L: Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005 Jul 8;280(27):25571-9. Epub 2005 May 3. FGF-1 induced the expression of HO-1 in cultured rat spinal cord astrocytes, which was dependent on FGF receptor activation and prevented by cycloheximide. Overexpression of Nrf2 in astrocytes increased survival of co-cultured embryonic motor neurons and prevented motor neuron apoptosis mediated by nerve growth factor through p75 neurotrophin receptor. |
1(0,0,0,1) | Details |
| 19158291 | Roche FK, Marsick BM, Letourneau PC: Protein synthesis in distal axons is not required for growth cone responses to guidance cues. J Neurosci. 2009 Jan 21;29(3):638-52. In the presence of cycloheximide or anisomycin, ephrin-A2, slit-3, and semaphorin3A still induced growth cone collapse and loss of actin filaments, nerve growth factor (NGF) and neurotrophin-3 still induced growth cone protrusion and increased filamentous actin, and sensory growth cones turned toward an NGF source. |
6(0,0,1,1) | Details |
| 15969743 | Pannaccione A, Secondo A, Scorziello A, Cali G, Taglialatela M, Annunziato L: Nuclear factor-kappaB activation by reactive species mediates voltage-gated K+ current enhancement by beta-amyloid peptides in nerve growth factor-differentiated PC-12 cells and hippocampal neurones. J Neurochem. 2005 Aug;94(3):572-86. Epub 2005 Jun 22. Inhibition of protein synthesis (cycloheximide, 1 microg/mL) and transcription (actinomycin D, 50 ng/mL) blocked Abeta (25-35)-induced VGK current enhancement, suggesting that this potentiation is mediated by transcriptional activation induced by ROS. |
2(0,0,0,2) | Details |
| 17026526 | Morsink MC, Joels M, Sarabdjitsingh RA, Meijer OC, De Kloet ER, Datson NA: The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells. J Neurochem. 2006 Nov;99(4):1282-98. Epub 2006 Oct 2. For this purpose, nerve growth factor-differentiated catecholaminergic PC12 cells were used in which endogenous GRs were activated briefly with a high dose of followed by gene expression profiling 1 and 3 h afterwards using Affymetrix GeneChips. Real-time quantatitive PCR of transcripts in cycloheximide-treated cells showed that all five GR-responsive genes selected from the 1-h time point were primary responsive, whereas all four GR-responsive genes selected from the 3-h time point were downstream responsive. |
1(0,0,0,1) | Details |
| 19438724 | Terasawa K, Ichimura A, Sato F, Shimizu K, Tsujimoto G: Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells. FEBS J. 2009 Jun;276(12):3269-76. Epub 2009 Apr 25. We found that expression of miR-221 and miR-222 expression were induced by nerve growth factor (NGF) stimulation in PC12 cells, and that this induction was dependent on sustained activation of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway. |
1(0,0,0,1) | Details |