| Name | eIF 4E |
|---|---|
| Synonyms | 4EHP; CBP; EIF4F; EIF4E; EIF4E1; EIF4EL1; EIF4EL3; Eukaryotic translation initiation factor 4E… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15578516 | Marienfeld C, Yamagiwa Y, Ueno Y, Chiasson V, Brooks L, Meng F, Patel T: Translational regulation of XIAP expression and cell survival during hypoxia in human cholangiocarcinoma. Gastroenterology. 2004 Dec;127(6):1787-97. Translational processes were deregulated by cycloheximide or rapamycin or by targeted deletion of eukaryotic initiation factor (eIF)-4E, a rate-limiting translational initiation factor using small interfering RNA (siRNA). |
84(1,1,1,4) | Details |
| 18030348 | Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jeno P, Arrieumerlou C, Hall MN: PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One. 2007 Nov 21;2(11):e1217. PRAS40 inhibits mTORC1 autophosphorylation and mTORC1 kinase activity toward eIF-4E binding protein (4E-BP) and PRAS40 itself. HeLa cells in which PRAS40 was knocked down were protected against induction of apoptosis by TNFalpha and cycloheximide. |
1(0,0,0,1) | Details |
| 15753296 | Gao Q, Das B, Sherman F, Maquat LE: Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4258-63. Epub 2005 Mar 7. |
1(0,0,0,1) | Details |
| 17652445 | Purdom-Dickinson SE, Sheveleva EV, Sun H, Chen QM: Translational control of nrf2 protein in activation of antioxidant response by oxidants. Mol Pharmacol. 2007 Oct;72(4):1074-81. Epub 2007 Jul 25. H (2) O (2) also induced phosphorylation of eukaryotic translation initiation factor (eIF) 4E and eIF2alpha within 30 and 10 min, respectively. Although inhibiting protein synthesis with cycloheximide prevented H (2) O (2) from elevating Nrf2 protein level, RNA synthesis inhibition with actinomycin D failed to do so. |
1(0,0,0,1) | Details |