| Name | RANKL |
|---|---|
| Synonyms | CD254; ODF; SODF; CD254 antigen; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17295206 | Uchiyama S, Yamaguchi M: and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells. J Cell Biochem. 2007 Jun 1;101(3):529-42. plus zinc-induced increase in caspase-3 mRNA expression was completely inhibited in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 10 (-6) M), an inhibitor of transcription activity. |
7(0,0,0,7) | Details |
| 18636177 | Yamaguchi M, Uchiyama S: Combination of and zinc has potent effects on apoptotic cell death and suppression of bone resorption-related gene expression in osteoclastic cells. Int J Mol Med. 2008 Aug;22(2):221-8. CRP plus zinc-induced increase in caspase-3 mRNA expression was completely inhibited in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DBR; 10 (-6) M), an inhibitor of transcription activity. The macrophage colony-stimulating factor (M-CSF)-dependent bone marrow macrophages were cultured in the presence of M-CSF (10 ng/ml) and receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL; 50 ng/ml) for 96 h. |
6(0,0,0,6) | Details |
| 16297161 | Hormdee D, Nagasawa T, Kiji M, Yashiro R, Kobayashi H, Koshy G, Noguchi K, Nitta H, Ishikawa I: Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol. 2005 Dec;142(3):490-7. Expression of receptor activator of nuclear factor kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG), by osteoblasts is important to regulate osteoclast differentiation. Human gingival fibroblasts (HGF) and periodontal ligament fibroblasts (PDL) were stimulated with IL-1alpha with or without protein synthesis inhibitor cycloheximide (CHX), protein kinase A (PKA) inhibitors, protein kinase C (PKC) inhibitors and (2) (PGE (2)) inhibitor. |
3(0,0,0,3) | Details |
| 18565131 | Arayatrakoollikit U, Pavasant P, Yongchaitrakul T: Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3'-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells. J Periodontal Res. 2008 Oct;43(5):537-43. Epub 2008 Jun 28. The mRNA expression and protein synthesis of OPG, as well as of receptor activator of nuclear factor kappaB ligand (RANKL), were determined by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis, respectively. The inductive effect was inhibited by cycloheximide, but not by indomethacin. |
2(0,0,0,2) | Details |
| 17143556 | Lai YL, Yamaguchi M: Phytocomponent inhibits osteoclast-like cell formation in mouse bone marrow cultures. Int J Mol Med. 2007 Jan;19(1):123-8. The inhibitory effect of HCA (10 (-6) or 10 (-5) M) on RANKL plus M-CSF-induced osteoclast-like cell formation was not observed in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis in the transcriptional process, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (10 (-6) M), an inhibitor of transcription. Also, HCA (10 (-8)-10 (-5) M) had a significant inhibitory effect on osteoclast-like cell formation induced by the receptor activator of NF-kappaB ligand (RANKL) (10 ng/ml) in the presence of macrophage colony-stimulating factor (M-CSF) (10 ng/ml). |
2(0,0,0,2) | Details |