| Name | factor VIIa |
|---|---|
| Synonyms | Coagulation factor VII; Coagulation factor VII precursor; Cogulation factor VII; Eptacog alfa; F7; FVII coagulation protein; Factor VII; Factor VII active site mutant immunoconjugate… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16525587 | Zacharowski K, Sucker C, Zacharowski P, Hartmann M: Thrombelastography for the monitoring of lipopolysaccharide induced activation of coagulation. Thromb Haemost. 2006 Mar;95(3):557-61. Experiments with the protein synthesis inhibitor cycloheximide and active site-inhibited factor VIIa revealed that LPS exerts its effects via the synthesis of tissue factor. |
81(1,1,1,1) | Details |
| 19439685 | Hartmann M, Ozlugedik S, Peters J: Thiopental inhibits lipopolysaccharide-induced tissue factor expression. Anesth Analg. 2009 Jul;109(1):109-13. Epub 2009 May 13. After recalcification, clotting time (CT) was determined by rotational thrombelastometry. (ii) The mechanism of the LPS-induced shortening of CT was investigated using the tissue factor blocker active-site inhibited factor VIIa and the protein synthesis inhibitor cycloheximide. (iii) A concentration response curve for the effect of tissue factor on CT was generated. |
81(1,1,1,1) | Details |
| 17892553 | Sucker C, Zacharowski K, Thielmann M, Hartmann M: Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood. Thromb J. 2007 Sep 24;5:13. This LPS effect was mediated by tissue factor, as inhibition with active site-inhibited factor VIIa (ASIS) abolished the effect of LPS on clotting time. Blockade of protein synthesis using cycloheximide demonstrated that LPS exerted its procoagulatory effect via an induction of tissue factor expression. |
1(0,0,0,1) | Details |