| Name | calpain inhibitors |
|---|---|
| Synonyms | BS 17; CAST; Calpain inhibitor; Calpastatin; Calpastatin isoform a; Heart type calpastatin; Sperm BS 17 component; Calpain inhibitors… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18647593 | Ozaki Y, Kato T, Kitagawa M, Fujita H, Kitagawa S: Calpain inhibition delays neutrophil apoptosis via cyclic AMP-independent activation of protein kinase A and protein kinase A-mediated stabilization of Mcl-1 and X-linked inhibitor of apoptosis (XIAP). Arch Biochem Biophys. 2008 Sep 15;477(2):227-31. Epub 2008 Jul 11. Calpain inhibitors (PD150606 and N-acetyl---Nle-CHO) prevented spontaneous neutrophil apoptosis and degradation of Mcl-1 and XIAP, and the effects of calpain inhibitors on neutrophils were resistant to cycloheximide. |
32(0,1,1,2) | Details |
| 17097791 | Lock EA, Reed CJ, Kinsey GR, Schnellmann RG: Caspase-dependent and -independent induction of externalization during apoptosis in human renal carcinoma Cak (1)-1 and A-498 cells. Toxicology. 2007 Jan 5;229(1-2):79-90. Epub 2006 Oct 13. The endonuclease inhibitor aurintricarboxylic acid (ATA), phospholipase A (2) inhibitor bromoenol lactone (BEL), protein synthesis inhibitor cycloheximide (CH) and chloride channel blockers niflumic acid (NFA) and 5-nitro-2-(3-phenylpropylamino) (NPPB) all had no effect on staurosporine-induced annexin V binding in A-498 cells either in the presence or absence of ZVAD. |
0(0,0,0,0) | Details |
| 19545424 | Liu T, Schneider RA, Shah V, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG: Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells. J Inflamm. 2009 Jun 22;6:20. Cells were treated with LPS/IFN, calpain inhibitors (carbobenzoxy-valinyl-phenylalaninal (zVF), PD150606), cycloheximide and COX inhibitors to determine the effect of PIN1 depletion on COX-2 and calpain. |
32(0,1,1,2) | Details |
| 18571867 | Nishio T, Kawaguchi S, Fujiwara H: Emergence of highly neurofilament-immunoreactive zipper-like axon segments at the transection site in scalpel-cordotomized adult rats. Neuroscience. 2008 Jul 31;155(1):90-103. Epub 2008 May 9. Local treatment with cycloheximide suppressed the axotomy-induced peripherin-IR-enhancement in severed ends, suggesting the occurrence of intra-axonal peripherin synthesis in vivo. Treatment with calpain inhibitors frequently formed abnormally swollen microtubule-free ends, which suggests that calpain-activation is critical for functional growth cone formation in adult rat spinal cord. |
1(0,0,0,1) | Details |
| 18266973 | Gressner OA, Lahme B, Siluschek M, Rehbein K, Herrmann J, Weiskirchen R, Gressner AM: Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor. J Cell Mol Med. 2008 Dec;12(6B):2717-30. Epub 2008 Feb 4. Cycloheximide did not abolish the rapid immunocytochemical appearance of mature TGF-beta, but calpain inhibitors partially suppressed intracellular TGF-beta activation and subsequently CTGF up-regulation. |
0(0,0,0,0) | Details |
| 18650263 | Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG: Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible synthase in endothelial cells. Am J Physiol Cell Physiol. 2008 Sep;295(3):C819-27. Epub 2008 Jul 23. Consistent with posttranscriptional action, knockdown of PIN1 increased the stability of iNOS protein in cycloheximide-treated cells. |
0(0,0,0,0) | Details |
| 19737590 | Yoshikawa N, Nemoto T, Satoh S, Maruta T, Yanagita T, Chosa E, Wada A: Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in chromaffin cells. Neurochem Int. 2010 Jan;56(1):42-50. Epub 2009 Sep 6. Geldanamycin-induced increase of insulin receptor substrate-2 was prevented by cycloheximide or actinomycin D. |
0(0,0,0,0) | Details |
| 18718443 | Rasbach KA, Green PT, Schnellmann RG: Oxidants and Ca+2 induce PGC-1alpha degradation through calpain. . Arch Biochem Biophys. 2008 Oct 15;478(2):130-5. Epub 2008 Aug 8. Under basal conditions, treatment with the protein synthesis inhibitor cycloheximide resulted in rapid degradation of PGC-1alpha (t (1/2)=38 min), which was blocked by the proteasome inhibitor epoxomicin, but not the calpain inhibitor calpeptin. |
0(0,0,0,0) | Details |