| Name | elongation factor 2 |
|---|---|
| Synonyms | EEF 2; EEF2; EF 2; EF2; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase; Elongation factor 2s… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15534876 | Elo MA, Karjalainen HM, Sironen RK, Valmu L, Redpath NT, Browne GJ, Kalkkinen N, Helminen HJ, Lammi MJ: High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2. J Cell Biochem. 2005 Feb 15;94(3):497-507. Cycloheximide addition after 4 h-pressure treatment suggested that the half-life of eEF-2 protein was shorter in pressurized cells. eEF-2 is responsible for the translocation of ribosome along the specific mRNA during translation, and its phosphorylation prevents the ribosomal translocation. |
37(0,1,1,7) | Details |
| 16606372 | Cossenza M, Cadilhe DV, Coutinho RN, Paes-de-Carvalho R: Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of production. J Neurochem. 2006 Jun;97(5):1481-93. Epub 2006 Apr 10. Although L-[3H] uptake measured in cultured chick retina cells incubated in the presence of cycloheximide (CHX, a protein synthesis inhibitor) was inhibited approximately 75% at equilibrium, quantitative thin-layer chromatography analysis showed that free intracellular L-[3H] was six times higher in CHX-treated than in control cultures. Western blot analysis revealed that stimulates the phosphorylation of eukaryotic elongation factor 2 (eEF2, a factor involved in protein translation), an effect inhibited by (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine (MK801). |
1(0,0,0,1) | Details |
| 18493739 | Wang Q, Heimberg H, Pipeleers D, Ling Z: Glibenclamide activates translation in rat pancreatic beta cells through -dependent mTOR, PKA and MEK signalling pathways. Diabetologia. 2008 Jul;51(7):1202-12. Epub 2008 May 21. Since it was blocked by the translation inhibitor cycloheximide, we examined whether sustained exposure to glibenclamide activates translational factors by -dependent signalling pathways. RESULTS: A 24 h exposure to glibenclamide induced activation of four translation factors, i.e. phosphorylation of eukaryotic initiation factor (eIF) 4e binding protein 1 and ribosomal protein S6 (rpS6), and dephosphorylation of eIF-2alpha and eukaryotic elongation factor 2. |
1(0,0,0,1) | Details |
| 19221463 | Py BF, Boyce M, Yuan J: A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. Autophagy. 2009 Apr;5(3):393-6. Epub 2009 Apr 6. Here, we provide evidence that eIF2alpha phosphorylation is required for phosphorylation of eukaryotic elongation factor 2 (eEF-2) during nutrient starvation. |
3(0,0,0,3) | Details |
| 20190073 | Leitsch D, Kohsler M, Marchetti-Deschmann M, Deutsch A, Allmaier G, Duchene M, Walochnik J: A major role for proteases during the early phase of Acanthamoeba castellanii encystment. Eukaryot Cell. 2010 Feb 26. Truncated actin isoforms were found to abound in the encysting cell and the levels of translation elongation factor 2 (EF2) were sharply decreased, indicating that the rate of protein synthesis must be low at this stage. The protease inhibitors PMSF and E64d inhibited the onset of encystment, whereas the protein synthesis inhibitor cycloheximide was ineffective. |
2(0,0,0,2) | Details |
| 15772076 | Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG: The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16. Finally, we show that the ability of energy depletion (which impairs mTOR signaling in TSC2+/+ cells) to increase the phosphorylation of eukaryotic elongation factor 2 is also independent of TSC2. |
1(0,0,0,1) | Details |
| 18614030 | Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF: Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron. 2008 Jul 10;59(1):70-83. |
1(0,0,0,1) | Details |