Protein Information

Name UGT1A6
Synonyms GNT1; UGT 1; UGT1; GNT1; UDPGT; HLUGP; HLUGP 1; HLUGP1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16274708 Heurtaux T, Benani A, Moulin D, Muller N, Netter P, Minn A: Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes. . Neuropharmacology. 2006 Mar;50(3):317-28. Epub 2005 Nov 7.

Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
85(1,1,1,5) Details
17110078 El-Sayed WM, Aboul-Fadl T, Roberts JC, Lamb JG, Franklin MR: Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol In Vitro. 2007 Feb;21(1):157-64. Epub 2006 Oct 7.

Induction responses to the selenazolidines were also eliminated (most) or reduced (Txnrd1 by 2-methylSCA) by cycloheximide, with the exception of Ugt1a6.
39(0,1,2,4) Details