Protein Information

Name CXCR2
Synonyms CD182; IL8RA; CD182 antigen; CDw128b; CMKAR 2; CMKAR2; CXCR 2; CXCR2…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17405813 Neel NF, Lapierre LA, Goldenring JR, Richmond A: RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci. 2007 May 1;120(Pt 9):1559-71. Epub 2007 Apr 3.

9(0,0,0,9) Details
16118408 Stefanovic L, Brenner DA, Stefanovic B: Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Exp Biol Med. 2005 Sep;230(8):573-86.


Hepatic stellate cells constitutively express the KC receptor, CXCR2.
3(0,0,0,3) Details
20178462 Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, Steffens G: Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2010 Feb 22.

Abstract Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that was recently identified as a non-cognate ligand of the chemokine receptors CXCR2 and CXCR4.
Early hypoxia-triggered MIF secretion was not inhibited by cycloheximide and echinomycin, inhibitors of general and HIF-1alpha-induced protein synthesis, respectively.
1(0,0,0,1) Details
18816377 Wang JG, Strong JA, Xie W, Yang RH, Coyle DE, Wick DM, Dorsey ED, Zhang JM: The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Mol Pain. 2008 Sep 24;4:38.

Neurons and glia express its receptor (CXCR2).
These effects required long exposures, and were completely blocked by co-incubation with protein synthesis inhibitor cycloheximide.
2(0,0,0,2) Details