| Name | NHE1 |
|---|---|
| Synonyms | APNH; APNH 1; APNH1; NHE 1; NHE1; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; SLC9A1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18715944 | Leite-Dellova DC, Oliveira-Souza M, Malnic G, Mello-Aires M: Genomic and nongenomic dose-dependent biphasic effect of on Na+/H+ exchanger in proximal S3 segment: role of cytosolic Am J Physiol Renal Physiol. 2008 Nov;295(5):F1342-52. Epub 2008 Aug 20. Spironolactone, actinomycin D, or cycloheximide did not affect the effects of (15- or 2-min pi) but inhibited the effects of (1-h pi) on pHirr and on [Ca2+] i. The data indicate a genomic (1 h, via MR) and a nongenomic action (15 or 2 min, probably via GR) on [Ca2+] i and on the basolateral NHE1 and are compatible with stimulation of the NHE1 by increases in [Ca2+] i in the lower range (at 10 (-12) M and inhibition by increases at high levels (at 10 (-6) M or decreases in [Ca2+] i (at 10 (-6) M plus RU 486). |
1(0,0,0,1) | Details |
| 16495213 | Carraro-Lacroix LR, Ramirez MA, Zorn TM, Reboucas NA, Malnic G: Increased NHE1 expression is associated with serum deprivation-induced differentiation in immortalized rat proximal tubule cells. Am J Physiol Renal Physiol. 2006 Jul;291(1):F129-39. Epub 2006 Feb 21. The altered activity of NHE1 was consistent with an increase of both transcription and translation of the antiporter, as the utilization of actinomycin D and cycloheximide significantly inhibited the upregulation of NHE1 induced by serum withdrawal. |
84(1,1,1,4) | Details |
| 18404734 | Tattersall AL, Wilkins RJ: Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes. J Orthop Res. 2008 Nov;26(11):1428-33. NHE3 activity was not detected in IGF-1-treated cells that had been incubated with the protein synthesis inhibitor cycloheximide, although NHE1 activity was unaffected. |
5(0,0,0,5) | Details |