| Name | IkappaB kinase |
|---|---|
| Synonyms | CHUK; IkappaB kinase; Conserved helix loop ubiquitous kinase; Conserved helix loop helix ubiquitous kinase; Conserved helix loop helix ubiquitous kinase variant; I kappa B kinase 1; I kappa B kinase alpha; IKBKA… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15782119 | Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S: Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005 Jun 2;24(24):3976-86. In addition, treatment with a protein synthesis inhibitor cycloheximide rapidly downregulated inhibitor of NF-kappaB (IkappaB) kinase activity in H-RS cells. |
82(1,1,1,2) | Details |
| 15619605 | Gravel SP, Servant MJ: Roles of an IkappaB kinase-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogen-induced proatherosclerotic conditions. J Biol Chem. 2005 Mar 4;280(9):7477-86. Epub 2004 Dec 24. |
2(0,0,0,2) | Details |
| 15878527 | Miura H, Maeda M, Yamamoto N, Yamaoka S: Distinct IkappaB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells. Exp Cell Res. 2005 Aug 1;308(1):29-40. Protein synthesis inhibition for 4 h by cycloheximide (CHX) barely affects IKK activity in Tax-positive HTLV-I-transformed cells, while it diminishes IKK activity in Tax-negative ATL cells. |
1(0,0,0,1) | Details |
| 18334598 | Zangar RC, Bollinger N, Verma S, Karin NJ, Lu Y: The nuclear factor-kappa B pathway regulates cytochrome P450 3A4 protein stability. Mol Pharmacol. 2008 Jun;73(6):1652-8. Epub 2008 Mar 11. We also found that MG132 treatment had a broad affect on the NF-kappaB pathway, including down-regulation of NF-kappaB DNA binding activity and IkappaB kinase (IKK) alpha levels and up-regulation of IKKbeta and inhibitory kappaB levels. When the HepG2 cells were treated with cycloheximide, a general inhibitor of protein synthesis, the loss of CYP3A4 protein was accelerated by cotreatment with either proteasome or NF-kappaB inhibitors. |
1(0,0,0,1) | Details |
| 18708082 | Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM: Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol. 2008 Nov 1;232(3):396-407. Epub 2008 Jul 29. IL-1beta-induced cPLA2 expression and production was inhibited by actinomycin D and cycloheximide, indicating the involvement of transcriptional and translational events in these responses. |
0(0,0,0,0) | Details |