Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9144531 Cho WJ, Cha SJ, Do JW, Choi JY, Lee JY, Jeong CS, Cho KJ, Choi WS, Kang HS, Kim HD, Park JW: A novel 90-kDa stress protein induced in fish cells by fish rhabdovirus infection. Biochem Biophys Res Commun. 1997 Apr 17;233(2):316-9.

A 90 kDa cellular protein in a fish cell, CHSE-214, showed increased expression by the infection of infectious hematopoietic necrosis virus (IHNV), heat shock, 2-mercaptoethanol, copper sulfate, and cadmium sulfate, and was detected in various kinds of cells such as human, rat, and mouse cells.
The present results indicate that the 90 kDa protein is a kind of stress protein.
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6234304 Anderson WL, Tomasi TB: Suppression of lymphocyte proliferation by copper-albumin chelates. . J Biol Chem. 1984 Jun 25;259(12):7602-6.


Inhibitory effects on the incorporation of [3H] leucine into trichloroacetic acid-precipitable protein is observed only at concentrations of Cu2+-Alb above 1 mg/ml.
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9093389 Kimura T, Nishioka H: Intracellular generation of superoxide by copper sulphate in Escherichia coli. Mutat Res. 1997 Mar 17;389(2-3):237-42.


In the system, SoxR protein is the superoxide-sensitive activator of the soxS gene.
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9801796 Macreadie I, Sankovich S, Failla P, Lowe M, Curtain C, Castelli L, Azad A: HIV-1 Nef protein causes death in stressed yeast cells due to determinants near the N-terminus and elsewhere in Nef. Biochem Mol Biol Int. 1998 Oct;46(2):277-86.


The Human Immunodeficiency Virus type 1 (HIV-1) Nef protein is essential for AIDS pathogenesis.
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18688729 Huang W, Ma X, Wang Q, Gao Y, Xue Y, Niu X, Yu G, Liu Y: Significant improvement of stress tolerance in tobacco plants by overexpressing a stress-responsive aldehyde dehydrogenase gene from maize (Zea mays). Plant Mol Biol. 2008 Nov;68(4-5):451-63. Epub 2008 Aug 9.


Tomato stable transformation of construct expressing the ZmALDH22A1 signal peptide fused with yellow fluorescent protein (YFP) driven by the CaMV35S-promoter reveals that the fusion protein is targeted to plastid.
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16939237 Ge R, Zhang Y, Sun X, Watt RM, He QY, Huang JD, Wilcox DE, Sun H: Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn. J Am Chem Soc. 2006 Sep 6;128(35):11330-1.


In contrast, the in vivo (in E. coli) protection by the protein is in the order of Ni2+ > Bi3+ > Cu2+ approximately Zn2+.
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8501139 Lai YK, Shen CH, Cheng TJ, Hou MC, Lee WC: Enhanced phosphorylation of a 65 kDa protein is associated with rapid induction of stress proteins in 9L rat brain tumor cells. J Cell Biochem. 1993 Mar;51(3):369-79.

Induction of heat-shock proteins and glucose-regulated proteins in 9L rat brain tumor cells can be differentially elicited by sodium arsenite, cadmium chloride, zinc chloride, copper sulfate, sodium fluoride, and L-azetidine-2-carboxylic acid.
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12832419 Bertinato J, L'Abbe MR: Copper modulates the degradation of copper chaperone for Cu,Zn superoxide dismutase by the 26 S proteosome. J Biol Chem. 2003 Sep 12;278(37):35071-8. Epub 2003 Jun 27.


We have recently reported that CCS protein is increased in tissues of rats fed copper-deficient diets suggesting that copper may regulate CCS expression.
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