| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19439213 | Chen X, Choi IY, Chang TS, Noh YH, Shin CY, Wu CF, Ko KH, Kim WK: Pretreatment with interferon-gamma protects microglia from oxidative stress via up-regulation of Mn-SOD. Free Radic Biol Med. 2009 Apr 15;46(8):1204-10. Epub 2009 Feb 9. The cytoprotective effect of IFN-gamma pretreatment was abolished by the protein synthesis inhibitor cycloheximide. Among various antioxidant enzymes such as or /zinc superoxide dismutase (Mn-SOD or Cu/Zn-SOD), catalase, and peroxidase (GPx), only Mn-SOD was up-regulated in IFN-gamma-pretreated microglial cells. |
3(0,0,0,3) | Details |
| 16409300 | Binet F, Cavalli H, Moisan E, Girard D: Arsenic trioxide (AT) is a novel human neutrophil pro-apoptotic agent: effects of catalase on AT-induced apoptosis, degradation of cytoskeletal proteins and de novo protein synthesis. Br J Haematol. 2006 Feb;132(3):349-58. Cycloheximide partially reversed AT-induced apoptosis. |
3(0,0,0,3) | Details |
| 19463099 | Lushchak OV, Nykorak NZ, Ohdate T, Inoue Y, Lushchak VI: Inactivation of genes encoding superoxide dismutase modifies yeast response to S-nitrosoglutathione-induced stress. Biochemistry. 2009 Apr;74(4):445-51. The activity of catalase in all strains was enhanced by GSNO. Inhibition of protein synthesis by cycloheximide did not prevent the activation of SOD, but it prevented the activation of catalase. |
2(0,0,0,2) | Details |
| 19873875 | Lushchak OV, Lushchak VI: Possible pathways involved in activation of catalase and superoxide dismutase with sodium nitroprusside in yeast Saccharomyces cerevisiae. Ukr Biokhim Zh. 2009 Mar-Apr;81(2):34-9. Using inhibitors of mRNA (actinomycin D) and protein (cycloheximide) synthesis, the strain deficient in Yap1p, a master regulator coordinating yeast adaptive response to oxidative stress, we have found that these enzymes are up-regulated via synthesis of new molecules at transcription and translation levels. |
2(0,0,0,2) | Details |
| 16910777 | Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1295-305. The rate of aminotriazole-inhibited catalase activity also was increased when SOD2 is overexpressed and reflects a 1.6-fold increase in the steady-state production of H (2) O (2). |
2(0,0,0,2) | Details |
| 16982041 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: Neuroprotective effects of against oxidative stress on rat hippocampal slices. Chem Biol Interact. 2006 Nov 7;163(3):207-17. Epub 2006 Aug 18. Endogenous antioxidant enzymes activities (SOD, GSH-PX and catalase) in hippocampal slices were evaluated during the course of incubation. MK886 (5 microM; a noncompetitive inhibitor of proliferator-activated receptor [PPAR] alpha), BADGE (bisphenol A diglycidyl ether; 100 microM; an antagonist of PPARgamma) and cycloheximide (CHX; 30 microM; an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
2(0,0,0,2) | Details |
| 17018608 | Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone P, Petros JA, Marshall FF, Zhau HE, Chung LW: Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res. 2006 Oct 1;66(19):9519-26. Induction of ADAM9 protein in LNCaP or C4-2 cells can be completely abrogated by the administration of an antioxidant, ebselen, or genetic transfer of a peroxide degradative enzyme, catalase, suggesting that reactive species (ROS) are a common mediator. The induction of ADAM9 by stress can be inhibited by both actinomycin D and cycloheximide through increased gene transcription and protein synthesis. |
1(0,0,0,1) | Details |
| 16814338 | Chen YC, Chow JM, Lin CW, Wu CY, Shen SC: Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Toxicol Appl Pharmacol. 2006 Oct 15;216(2):263-73. Epub 2006 May 19. In the absence of H (2) O (2), BE induces ERKs protein phosphorylation, and HO-1 protein expression induced by BE was blocked by the addition of cycloheximide, actinomycin D, and the ERK inhibitor PD98059. Catalase addition prevented H (2) O (2)-induced ROS production, ERKs protein phosphorylation, and cell death, and BE dose-dependently inhibited H (2) O (2)-induced ERK protein phosphorylation in C6 cells. |
1(0,0,0,1) | Details |
| 15993699 | Fatima RA, Ahmad M: Certain antioxidant enzymes of Allium cepa as biomarkers for the detection of toxic heavy metals in wastewater. Sci Total Environ. 2005 Jun 15;346(1-3):256-73. In the presence of cycloheximide, all the enzymes returned to the levels of untreated controls while chloramphenicol did not have any effect on the test enzymes, thereby suggesting de novo protein synthesis of the test antioxidant enzymes in the cytosolic compartment of the cell as a result of exposure to the heavy metals. The utility of antioxidant enzymes, viz glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), peroxidase (APX), peroxidase (GPX), monodehydroascorbate reductase (MDHAR) and reductase (DHAR), as biomarkers of heavy metal pollution in water was investigated using the Allium cepa (onion) system. |
1(0,0,0,1) | Details |
| 16378625 | Wu CC, Hsu MC, Hsieh CW, Lin JB, Lai PH, Wung BS: Upregulation of heme oxygenase-1 by via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci. 2006 May 15;78(25):2889-97. Epub 2005 Dec 27. Furthermore, -mediated HO-1 induction was abrogated in the presence of actinomycin D and cycloheximide, indicating that this upregulation of HO-1 occurred at the transcriptional level. The inhibition of intracellular ROS production by (NAC), (GSH), superoxide dismutase (SOD), catalase and the mitochondrial complex I inhibitor, rotenone, results in a decrease in -dependent HO-1 expression. |
1(0,0,0,1) | Details |
| 16076025 | Danielisova V, Nemethova M, Gottlieb M, Burda J: Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition. Neurochem Res. 2005 Apr;30(4):559-65. The purpose of this study was to investigate the role of superoxide dismutase (SOD) and catalase (CAT) in brain ischemic tolerance induced by ischemic preconditioning. Our attempt to understand the mechanisms of increased SOD and CAT activities by application of protein synthesis inhibitor cycloheximide showed that this increase was caused by de novo synthesis of enzymes during first hours after ischemia. |
1(0,0,0,1) | Details |
| 16822952 | Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H: HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2006 Nov;291(5):C897-908. Epub 2006 Jul 5. The TNF-alpha response was inhibited by superoxide dismutase and catalase suggesting apoptosis is oxidative stress related. In CMVEC from mice and newborn pigs, 15 ng/ml TNF-alpha alone, or with 10 microg/ml cycloheximide (CHX) caused apoptosis detected by nuclear translocation of p65 NF-kappaB, caspase-3 activation, DNA fragmentation, cell-cell contact destabilization, and cell detachment. |
1(0,0,0,1) | Details |
| 19597706 | Rosado T, Conim A, Alves-Pereira I, Ferreira R: pentoxide effects on stress responses in wine Saccharomyces cerevisiae strain UE-ME3. Ecotoxicology. 2009 Nov;18(8):1116-22. Epub 2009 Jul 12. Our results show that 2.0 mM pentoxide in culture medium induced a significant increase of malonaldehyde level and peroxidase activity, a slightly increase of Catalase A activity as well as a decrease of wet weight and mitochondrial cit c reductase of S. cerevisiae UE-ME (3). Also our results show that cycloheximide prevent cell death when cells grows 30 min in presence of 1.5 mM of pentoxide. |
1(0,0,0,1) | Details |
| 16585560 | Yoshioka Y, Kitao T, Kishino T, Yamamuro A, Maeda S: protects macrophages from peroxide-induced apoptosis by inducing the formation of catalase. J Immunol. 2006 Apr 15;176(8):4675-81. Cycloheximide, a protein synthesis inhibitor, inhibited both the NO-induced increase in the catalase level and the cytoprotective effect of NO. |
1(0,0,0,1) | Details |
| 18647484 | Lushchak OV, Lushchak VI: Sodium nitroprusside induces mild oxidative stress in Saccharomyces cerevisiae. Redox Rep. 2008;13(4):144-52. Yeast incubation with SNP increased the activities of catalase and superoxide dismutase. Cycloheximide, an inhibitor of translation, blocked SNP-induced catalase activation, but not SOD activation. |
1(0,0,0,1) | Details |
| 15839099 | Angelova MB, Pashova SB, Spasova BK, Vassilev SV, Slokoska LS: Oxidative stress response of filamentous fungi induced by peroxide and paraquat. Mycol Res. 2005 Feb;109(Pt 2):150-8. Cell responses against both and peroxide stresses include enhanced expression of superoxide dismutase (SOD) and catalase, however, the extent was different: treatment with PQ increased mainly SOD, whereas exogenous H2O2 led to enhanced catalase. The activation of antioxidant enzyme defence was blocked by the translation inhibitor, cycloheximide, suggesting that there was de novo enzyme synthesis. |
1(0,0,0,1) | Details |
| 15819811 | Ajamieh HH, Berlanga J, Merino N, Sanchez GM, Carmona AM, Cepero SM, Giuliani A, Re L, Leon OS: Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion. Transpl Int. 2005 May;18(5):604-12. Rats were treated with cycloheximide (CHX) in order to promote protein synthesis inhibition after OzoneOP treatment. Plasma transaminases, malondialdehyde and 4-hydroxyalkenals and morphological characteristics were measured as an index of hepatocellular damage; Cu/Zn-superoxide dismutase (SOD), Mn-SOD, catalase, total hydroperoxides and levels as markers of endogenous antioxidant system. |
1(0,0,0,1) | Details |
| 17641050 | Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Mutlu GM, Budinger GR: The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol. 2007 Aug 1;179(3):1834-41. We sought to determine whether LPS and cycloheximide-induced cell death in human lung microvascular endothelial cells (HmVECs) was dependent upon activation of the intrinsic apoptotic pathway and the generation of reactive species. |
0(0,0,0,0) | Details |
| 19835160 | Qu P, Deng X, Zhang J, Chen J, Zhang J, Zhang Q, Xiao Y, Chen S: [Identification and characterization of the Francisella sp. strain 08HL01032 isolated in air condition systems]. Wei Sheng Wu Xue Bao. 2009 Aug 4;49(8):1003-10. RESULTS: Strain 08H101032 was Gram-negative with polymorphic short rods or coccobacillus; with no flagella; devoid of spores; well growth on buffered charcoal yeast extraction (BCYE) agar and BCYE supplemented with (3 g/L), polymyxin B sulfate (80000 iu/L), vancomycin (1 mg/L) and cycloheximide (80 mg/L) (GVPC medium) within 2 days, but delayed growth on ordinary sheep blood agar untill 5 - 7 days; catalase positive; oxidase negative; no reduction of no hydrolysis of urea; delayed fermention of to produce acid; which was primarily considered as Legionella. |
0(0,0,0,0) | Details |
| 19294337 | Cardin GB, Mantha M, Jumarie C: Resistance to cadmium as a function of Caco-2 cell differentiation: role of reactive species in cadmium- but not zinc-induced adaptation mechanisms. Biometals. 2009 Oct;22(5):753-69. Epub 2009 Mar 18. However, the results obtained with cycloheximide used for inhibiting protein synthesis and with L-buthionine sulfoximine (BSO), which inhibits GSH synthesis, revealed that protein synthesis is not a prerequisite to the development of resistance. |
0(0,0,0,0) | Details |
| 19646526 | Lee JY, Jung HJ, Song IS, Williams MS, Choi C, Rhee SG, Kim J, Kang SW: Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells. Free Radic Biol Med. 2009 Oct 15;47(8):1162-71. Epub 2009 Jul 29. The HeLa cervical cancer cells expressing a dominant negative mutant (DN) of a cytosolic 2-cysPrx manifested remarkable increase in intracellular reactive species level, which was counteracted by catalase administration, and apoptotic cell death induced by combined treatment of TNF-alpha and cycloheximide compared to the control (CT) cells. |
0(0,0,0,0) | Details |
| 18005266 | Ratthe C, Girard D: Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression. Br J Haematol. 2008 Jan;140(1):59-70. Epub 2007 Nov 12. Utilization of catalase, cycloheximide and inhibitors showed that IL-4 induced SOCS3 by a mechanism dependent on a complete oxidase complex, protein synthesis and phosphorylation, but independent of production of reactive species. |
81(1,1,1,1) | Details |
| 17302992 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: protects primary cultured cortical neurons against oxidative stress. Acta Pharmacol Sin. 2007 Mar;28(3):315-26. Endogenous antioxidant enzymes activity [superoxide dismutases (SOD), peroxidase (GSH-Px), and catalase (CAT)] and lipid peroxidation in cultured cortical neurons were evaluated using commercial kits. {3-[1 (p-chlorobenzyl)- 5-(isopropyl)-3-t-butylthiondol-2-yl]-2,2-dimethylpropanoic acid, Na} [MK886; 5 micromol/L; a noncompetitive inhibitor of proliferator-activated receptor (PPAR) alpha], bisphenol A diglycidyl ether (BADGE; 100 micromol/L; an antagonist of PPAR gamma), and cycloheximide (CHX; 30 micromol/L, an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
31(0,1,1,1) | Details |
| 20228545 | Chaudhary R, Singh S, Banerjee T, Tilak R: Prevalence of different Malassezia species in pityriasis versicolor in central India. Indian J Dermatol Venereol Leprol. 2010 Mar-Apr;76(2):159-64. METHODS: In 100 patients with pityriasis versicolor, Malassezia species were identified by culture in Sabouraud's agar containing cycloheximide with olive oil overlay and modified Dixon agar and by doing biochemical tests (catalase reaction, assimilation of and Tween utilisation tests). |
81(1,1,1,1) | Details |
| 19017469 | Lushchak OV, Lushchak VI: Catalase modifies yeast Saccharomyces cerevisiae response towards S-nitrosoglutathione-induced stress. Redox Rep. 2008;13(6):283-91. Pre-incubation with cycloheximide prevented the activation of catalase, but not SOD. |
6(0,0,0,6) | Details |
| 17100288 | Bailiak MM, Semchyshyn HM, Lushchak VI: [Role of catalase and superoxide dismutase in the yeast Saccharomyces cerevisiae response to peroxide in exponential phase of growth]. Ukr Biokhim Zh. 2006 Mar-Apr;78(2):79-85. The effect was cancelled by cycloheximide, an inhibitor of protein synthesis. |
4(0,0,0,4) | Details |