| Name | Cx43 |
|---|---|
| Synonyms | CX43; Connexin 43; Cx43; DFNB38; GJA 1; GJA1; GJAL; Gap junction 43 kDa heart protein… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16613777 | Stahlhut M, Petersen JS, Hennan JK, Ramirez MT: The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes. Cell Commun Adhes. 2006 Jan-Apr;13(1-2):21-7. Cycloheximide (10 microg/ml) reduced Cx43 protein levels to 39% of vehicle (17 mM whereas cotreatment of 10 microg/ml cycloheximide with 100 nM rotigaptide reduced Cx43 protein levels to 56% of vehicle. |
87(1,1,1,7) | Details |
| 16754362 | Bazou D, Dowthwaite GP, Khan IM, Archer CW, Ralphs JR, Coakley WT: Gap junctional intercellular communication and cytoskeletal organization in chondrocytes in suspension in an ultrasound trap. Mol Membr Biol. 2006 Mar-Apr;23(2):195-205. Preincubation of cells with the protein synthesis inhibitor cycloheximide caused a six-fold decrease in Cx43 accumulation (as assessed by immunofluorescence) at the interfaces of chondrocytes in the aggregate. |
33(0,1,1,3) | Details |
| 15605363 | Arnold JM, Phipps MW, Chen J, Phipps J: Cellular sublocalization of Cx43 and the establishment of functional coupling in IMR-32 neuroblastoma cells. Mol Carcinog. 2005 Mar;42(3):159-69. |
6(0,0,0,6) | Details |
| 15561096 | Rivedal E, Leithe E: Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells. Exp Cell Res. 2005 Jan 15;302(2):143-52. The initial block in GJIC has been attributed to protein kinase C (PKC) mediated phosphorylation of connexin gap junction proteins, including connexin43 (Cx43). We show that coincubation of TPA with the protein synthesis inhibitor cycloheximide or the transcription inhibitor actinomycin D results in synergistic enhancement of the level of activated ERK1/2. |
5(0,0,0,5) | Details |
| 17123514 | Theiss C, Mazur A, Meller K, Mannherz HG: Changes in gap junction organization and decreased coupling during induced apoptosis in lens epithelial and NIH-3T3 cells. Exp Cell Res. 2007 Jan 1;313(1):38-52. Epub 2006 Oct 13. We demonstrate that global induction of apoptosis in primary bovine lens epithelial (LEC) or fibroblastic mouse NIH-3T3 cells by staurosporine, puromycin, cycloheximide, or etoposide is accompanied by a decrease in coupling by gap junctions. Immunohistochemistry using anti-connexin-43 antibodies showed a reduction of plasma membrane integrated connexin-43 in both cell lines when undergoing apoptosis. |
3(0,0,0,3) | Details |