| Name | peroxisome proliferator activated receptor |
|---|---|
| Synonyms | NR1C1; PPAR; PPAR alpha; PPARA; PPARalpha; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor alpha; hPPAR… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17089002 | Fiatte C, Huin C, Bertin I, Lesuffleur T, Pluvinet A, Touche N, Plenat F, Dauca M, Domenjoud L, Schohn H: Genetic analysis of peroxisome proliferator-activated receptor gamma1 splice variants in human colorectal cell lines. Int J Oncol. 2006 Dec;29(6):1601-10. HT-29 cells treatment with actinomycin D or cycloheximide showed that the presence of PPARgamma mRNA including exon A2 was dependent on de novo protein synthesis. |
1(0,0,0,1) | Details |
| 19118520 | Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A: Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun. 2009 Feb 13;379(3):743-8. Epub 2008 Dec 30. The TZD-induced REG Ialpha mRNA reduction was abolished by cycloheximide, indicating the necessity of novel protein (s) synthesis. |
0(0,0,0,0) | Details |
| 19843871 | Qi D, Cai K, Wang O, Li Z, Chen J, Deng B, Qian L, Le Y: Fatty acids induce amylin expression and secretion by pancreatic {beta}-cells. Am J Physiol Endocrinol Metab. 2009 Oct 20. Pretreatment of MIN6 cells with Ca (2+) chelator (EGTA, BAPTA/AM), protein kinase C (PKC) inhibitor Go6976, or protein synthesis inhibitor cycloheximide significantly inhibited FA-induced amylin mRNA expression. |
0(0,0,0,0) | Details |
| 17302992 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: protects primary cultured cortical neurons against oxidative stress. Acta Pharmacol Sin. 2007 Mar;28(3):315-26. Endogenous antioxidant enzymes activity [superoxide dismutases (SOD), peroxidase (GSH-Px), and catalase (CAT)] and lipid peroxidation in cultured cortical neurons were evaluated using commercial kits. {3-[1 (p-chlorobenzyl)- 5-(isopropyl)-3-t-butylthiondol-2-yl]-2,2-dimethylpropanoic acid, Na} [MK886; 5 micromol/L; a noncompetitive inhibitor of proliferator-activated receptor (PPAR) alpha], bisphenol A diglycidyl ether (BADGE; 100 micromol/L; an antagonist of PPAR gamma), and cycloheximide (CHX; 30 micromol/L, an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
81(1,1,1,1) | Details |
| 15939809 | Clasen R, Schupp M, Foryst-Ludwig A, Sprang C, Clemenz M, Krikov M, Thone-Reineke C, Unger T, Kintscher U: PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension. 2005 Jul;46(1):137-43. Epub 2005 Jun 6. Kinetic studies using the protein synthesis inhibitor cycloheximide showed that irbesartan prevented the cellular depletion of adiponectin protein. Recently, certain ARBs (irbesartan, telmisartan) were identified as ligands of the peroxisome proliferator-activated receptor (PPAR) gamma. |
1(0,0,0,1) | Details |
| 20038583 | Guntur KV, Guilherme A, Xue L, Chawla A, Czech MP: Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes. J Biol Chem. 2010 Feb 26;285(9):6595-603. Epub 2009 Dec 28. PPARgamma degradation rates are remarkably rapid as measured in the presence of cycloheximide (t (1/2) = 2 h), but silencing Map4k4 had no effect on PPARgamma degradation. |
1(0,0,0,1) | Details |
| 16675452 | Chou YT, Yang YC: Post-transcriptional control of Cited2 by transforming growth factor beta. J Biol Chem. 2006 Jul 7;281(27):18451-62. Epub 2006 May 4. Pharmacologic inhibition of translation with cycloheximide attenuated Cited2 down-regulation by TGF-beta. Cited2 interacts with cAMP-responsive element-binding protein-binding protein (CBP)/p300, TFAP2, Lhx2, and nuclear receptors, such as peroxisome proliferator-activated receptor and estrogen receptor to function as a transcriptional modulator. |
1(0,0,0,1) | Details |
| 18281744 | Poczatkova H, Bogdanova K, Uherkova L, Cervenkova K, Riegrova D, Rypka M, Vesely J: effects on the mRNA levels of peroxisome proliferator-activated receptors and their coactivators in human hepatoma HepG2 cells. Gen Physiol Biophys. 2007 Dec;26(4):268-74. Basal mRNA levels of PPAR-alpha and PGC-1alpha were significantly suppressed upon 20 h treatment with cycloheximide, while those of PPAR-gamma1, -gamma2, and PGC-1beta were elevated. |
167(2,2,2,7) | Details |
| 16982041 | Wang ZJ, Liang CL, Li GM, Yu CY, Yin M: Neuroprotective effects of against oxidative stress on rat hippocampal slices. Chem Biol Interact. 2006 Nov 7;163(3):207-17. Epub 2006 Aug 18. MK886 (5 microM; a noncompetitive inhibitor of proliferator-activated receptor [PPAR] alpha), BADGE (bisphenol A diglycidyl ether; 100 microM; an antagonist of PPARgamma) and cycloheximide (CHX; 30 microM; an inhibitor of protein synthesis) were tested for their effects on the neuroprotection afforded by |
81(1,1,1,1) | Details |
| 18345257 | Bogdanova K, Uherkova L, Poczatkova H, Rypka M, Vesely J: mRNA levels of peroxisome proliferator-activated receptors and their coactivators are affected by deprivation and in human hepatoma hepG2 cells. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec;151(2):237-45. PPAR-gamma1 and -gamma2 mRNAs were significantly superinduced when the cells were treated with cycloheximide, whereas PPAR-alpha and PGC-1alpha and-1beta mRNAs were destabilized. |
11(0,0,1,6) | Details |
| 19017711 | Ropero AB, Juan-Pico P, Rafacho A, Fuentes E, Bermudez-Silva FJ, Roche E, Quesada I, de Fonseca FR, Nadal A: Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. J Endocrinol. 2009 Feb;200(2):127-38. Epub 2008 Nov 18. The WY-14 643 action was rapid in onset (5 min) and was still produced in the presence of protein and mRNA synthesis inhibitors, cycloheximide, and actinomycin-d. |
8(0,0,0,8) | Details |
| 16150827 | Jiang YJ, Kim P, Elias PM, Feingold KR: LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. J Lipid Res. 2005 Dec;46(12):2657-66. Epub 2005 Sep 8. In addition, cycloheximide almost completely blocks the ciglitazone-induced increase in SULT2B1b mRNA, suggesting that the transcription of SULTB1b mRNA is dependent on new protein synthesis. |
7(0,0,0,7) | Details |
| 20208394 | Saito K, Kobayashi K, Mizuno Y, Fukuchi Y, Furihata T, Chiba K: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes. Drug Metab Pharmacokinet. 2010;25(1):108-11. Pretreatment of cells with cycloheximide, an inhibitor of protein synthesis, completely suppressed increase in CYP2B1/2 mRNA in response to ciprofibrate, suggesting that protein synthesis is required in this process. |
5(0,0,0,5) | Details |
| 17726147 | Jorgensen JA, Zadravec D, Jacobsson A: and synergistically induce Elovl3 expression in brown adipocytes. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1159-68. Epub 2007 Aug 28. By using primary cultures of brown adipocytes, we show here that the induced Elovl3 gene expression is synergistically regulated by and the peroxisome proliferator-activated receptor (PPAR) gamma ligand |
2(0,0,0,2) | Details |
| 15877607 | Kim HY, Kim HK, Kim JR, Kim HS: Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14- in mouse peritoneal macrophages. Immunol Cell Biol. 2005 Jun;83(3):286-93. 15-Deoxy-Delta (12,14)-prostaglandin J (2) (15d-PGJ (2)) was initially identified as a high affinity natural ligand for the peroxisome proliferator-activated receptor (PPAR)-gamma. |
1(0,0,0,1) | Details |