Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
15992939 Dewez D, Geoffroy L, Vernet G, Popovic R: Determination of photosynthetic and enzymatic biomarkers sensitivity used to evaluate toxic effects of copper and fludioxonil in alga Scenedesmus obliquus. Aquat Toxicol. 2005 Aug 30;74(2):150-9.


Under the same condition, enzymatic activities of catalase, ascorbate peroxidase, glutathione reductase and glutathione S-transferase were investigated to evaluate antioxidative response to fungicides effects.
2(0,0,0,2) Details
10930654 Paris-Palacios S, Biagianti-Risbourg S, Vernet G: Biochemical and (ultra) structural hepatic perturbations of Brachydanio rerio (Teleostei, Cyprinidae) exposed to two sublethal concentrations of copper sulfate. Aquat Toxicol. 2000 Aug 1;50(1-2):109-124.

Increase in hepatic protein content and of anti-oxidative defences (glutathione content, catalase and glutathione-S-transferase (GST) activities) indicated that the overall response of the liver was adaptative.
1(0,0,0,1) Details
18533248 Almeida DV, Trindade GS, Geracitano LA, Barros DM, Monserrat JM, Marins LF: Initial results in the development of a reporter cell line for toxicology studies at gene expression level: activation of the electrophile-responsive element by copper and methyl parathion. Mar Environ Res. 2008 Jul;66(1):158-60. Epub 2008 Mar 8.

In order to evaluate the molecular response triggered by these pollutants, a stable cell line was produced, which carries a transgene comprised of the green fluorescent protein (GFP) reporter gene under transcriptional control of the mouse glutathione-S-transferase (gst1) electrophile-responsive element fused to the mouse metallothionein (mt1) minimal promoter.
EpREmt-GFP HTC cells were treated with 0.002 mg L (-1), 0.02 mg L (-1), 0.2 mg L (-1) and 2 mg L (-1) copper sulfate and 0.001 mg L (-1), 0.01 mg L (-1), 0.1 mg L (-1) and 1 mg L (-1) methyl parathion for 48 h.
1(0,0,0,1) Details
19264136 Osuna-Jimenez I, Williams TD, Prieto-Alamo MJ, Abril N, Chipman JK, Pueyo C: Immune- and stress-related transcriptomic responses of Solea senegalensis stimulated with lipopolysaccharide and copper sulphate using heterologous cDNA microarrays. Fish Shellfish Immunol. 2009 May;26(5):699-706. Epub 2009 Mar 3.


Additionally transcripts for glutathione-S-transferases were down-regulated by LPS, and those for digestive enzymes were down-regulated by both treatments.
1(0,0,0,1) Details
16327069 Arabi M, Alaeddini MA: Metal-ion-mediated oxidative stress in the gill homogenate of rainbow trout (Oncorhynchus mykiss): antioxidant potential of manganese, selenium, and albumin. Biol Trace Elem Res. 2005 Winter;108(1-3):155-68.


This study was undertaken to evaluate the effects of copper and mercury at the 400- to 1000-microM concentration range on some biochemical markers of oxidative stress, such as lipid peroxidation (LPO), glutathione-S-transferase (GST) activity, and reduced glutathione (GSH) content in the rainbow trout gill homogenates with or without supplementation of manganese, selenium, and bovine serum albumin (BSA).
1(0,0,0,1) Details
19116768 Almeida DV, da Silva Nornberg BF, Geracitano LA, Barros DM, Monserrat JM, Marins LF: Induction of phase II enzymes and hsp70 genes by copper sulfate through the electrophile-responsive element (EpRE): insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin. Fish Physiol Biochem. 2009 Jan 1.

We have evaluated the homology of the electrophile-responsive element (EpRE) core sequence, a binding site for the Nrf2 transcription factor, in the proximal promoters of the mouse and zebrafish glutathione-S-transferase (gst), glutamate cysteine ligase catalytic subunit (gclc) and heat shock protein 70 (hsp70) genes.
1(0,0,0,1) Details
19665166 El-Gendy KS, Radwan MA, Gad AF: In vivo evaluation of oxidative stress biomarkers in the land snail, Theba pisana exposed to copper-based pesticides. Chemosphere. 2009 Oct;77(3):339-44. Epub 2009 Aug 7.


Oxidative individual perturbations were assessed by measuring non-enzymatic (glutathione; GSH) and enzymatic (catalase; CAT, glutathione peroxidase; GPx and glutathione S-transferase; GST) antioxidants in digestive gland of the snails.
1(0,0,0,1) Details