Protein Information

Name PABP
Synonyms PAB 1; PAB1; PABP; PABP 1; PABP1; PABPC 1; PABPC 2…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16887808 Kozak SL, Marin M, Rose KM, Bystrom C, Kabat D: The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules. J Biol Chem. 2006 Sep 29;281(39):29105-19. Epub 2006 Aug 3.

For example arsenite, which inhibits 5'-cap-dependent translational initiation, shifted mRNA-A3G-PABP from polysomes into stress granules in a manner that was blocked and reversed by the elongation inhibitor cycloheximide.
33(0,1,1,3) Details
20036288 Nadezhdina ES, Lomakin AJ, Shpilman AA, Chudinova EM, Ivanov PA: Microtubules govern stress granule mobility and dynamics. Biochim Biophys Acta. 2010 Mar;1803(3):361-371. Epub 2009 Dec 28.


In cycloheximide-treated cells SGs dissociated into constituent parts that then dissolved within the cytoplasm.
0(0,0,0,0) Details