| Name | CTCF |
|---|---|
| Synonyms | 11 zinc finger protein; CCCTC binding factor; CCCTC binding factor (zinc finger protein); CTCF; CTCFL paralog; Transcriptional repressor CTCF; CCCTC binding factors; CCCTC binding factor (zinc finger protein)s… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17082775 | Chen HL, Li T, Qiu XW, Wu J, Ling JQ, Sun ZH, Wang W, Chen W, Hou A, Vu TH, Hoffman AR, Hu JF: Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO J. 2006 Nov 15;25(22):5329-38. Epub 2006 Nov 2. Inhibition of the synthesis of putative trans imprinting factors with cycloheximide led to loss of IGF2 imprinting in normal cultured fibroblasts, suggesting that normal cells produce proteins that act in trans to induce or maintain genomic imprinting. These data demonstrate that an abnormal tumor epigenotype can be corrected by in vitro reprogramming, and suggest that loss of imprinting is associated with the loss of activity of non-CTCF trans imprinting that are either inactivated or mutated in tumors. |
1(0,0,0,1) | Details |
| 18974150 | Chan CS, Song JS: CCCTC-binding factor confines the distal action of estrogen receptor. . Cancer Res. 2008 Nov 1;68(21):9041-9. The proposed method combines a recent map of the insulator protein CCCTC-binding factor (CTCF) with previous ER location studies and expression profiling in the presence of the translation inhibitor cycloheximide, providing evidence that CTCF partitions the human genome into distinct ER-regulatory blocks. |
32(0,1,1,2) | Details |