Protein Information

Name lipoxygenase 12
Synonyms 12 LO; 12 lipoxygenase; 12 LOX; ALOX12; Arachidonate 12 oxidoreductase; LOG12; Platelet type 12 lipoxygenase/arachidonate 12 lipoxygenase protein; Platelet type lipoxygenase 12…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17379189 Weisinger G, Limor R, Marcus-Perlman Y, Knoll E, Kohen F, Schinder V, Firer M, Stern N: 12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 May 11;356(3):554-60. Epub 2007 Mar 12.

Upon angiotensin-II treatment of cultured VSMC, immunoprecipitated 12-LO was found bound to alpha-actin, a component of the cytoplasmic myofilaments. 12-LO/alpha-actin binding was blocked by VSMC pretreatment with the 12-LO inhibitors, baicalien or esculetine and the protein synthesis inhibitor, cycloheximide.
34(0,1,1,4) Details