Protein Information

Name heparan sulfate proteoglycans
Synonyms Fibroglycan; HSPG; HSPG 1; HSPG1; Heparan sulfate proteoglycan; Heparan sulfate proteoglycan 1 cell surface associated fibroglycan; Heparan sulfate proteoglycan core protein; SDC 2…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16629467 Yanagishita M, Tsuchida S, Yokoyama M, Inoue KA: [Effect of p-nitrophenyl-xyloside on the biosynthesis of proteoglycan in rat ovarian granulosa cells--analyses of glycosaminoglycan synthesis in the Golgi apparatus]. Kokubyo Gakkai Zasshi. 2006 Mar;73(1):20-5.

Biosynthesis of heparan sulfate proteoglycans was reduced by approximately 50%, likely due to competition at the level of UDP-sugar precursors. [35S] Sulfate incorporation was shut down by the addition of cycloheximide with an initial half time of approximately 2 hr in the presence of xyloside, while that in the absence of xyloside was about 20 min.
31(0,1,1,1) Details
16807246 Hayashida K, Johnston DR, Goldberger O, Park PW: Syndecan-1 expression in epithelial cells is induced by transforming growth factor beta through a PKA-dependent pathway. J Biol Chem. 2006 Aug 25;281(34):24365-74. Epub 2006 Jun 28.

Syndecans comprise a major family of cell surface heparan sulfate proteoglycans (HSPGs).
Steady-state syndecan-1 mRNA was not increased by TGFbeta treatment and cycloheximide did not inhibit syndecan-1 induction by TGFbeta, indicating that TGFbeta induces syndecan-1 in a post-translational manner.
1(0,0,0,1) Details