| Name | TIMP3 |
|---|---|
| Synonyms | HSMRK222; SFD; K222; K222TA2; MIG 5 protein; Metalloproteinase inhibitor 3; Metalloproteinase inhibitor 3 precursor; Protein MIG 5… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18029162 | Sampieri CL, Nuttall RK, Young DA, Goldspink D, Clark IM, Edwards DR: Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biol. 2008 Mar;27(2):128-38. Epub 2007 Oct 4. However, even though all inhibitors effectively blocked translation, PMA-induction of MMP9 and TIMP3 was blocked by emetine but was insensitive to cycloheximide and anisomycin. |
83(1,1,1,3) | Details |
| 18433744 | Ishikawa F, Nose K, Shibanuma M: Downregulation of hepatocyte nuclear factor-4alpha and its role in regulation of gene expression by TGF-beta in mammary epithelial cells. Exp Cell Res. 2008 Jun 10;314(10):2131-40. Epub 2008 Mar 29. The repression was interfered by dominant negative forms of activin receptor-like kinase 5 (ALK5) and Smad3, and sensitive to cycloheximide, suggesting the involvement of additional protein (s) as well as ALK5 and Smad3 in the repression. Therefore, it is likely that HMGA2 mediates the downregulation of HNF-4alpha8 downstream of ALK5 and Smads To determine the significance of the downregulation of HNF-4alpha8 in TGF-beta signaling, we performed DNA microarray analysis and extracted a subgroup of TGF-beta1-regulated genes, including tenascin C and tissue inhibitor of metalloproteinase 3 (TIMP-3), whose regulation by TGF-beta1 was attenuated by forced expression of HNF-4alpha8. |
1(0,0,0,1) | Details |
| 17763444 | Powell AJ, Little CB, Hughes CE: Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis Rheum. 2007 Sep;56(9):3010-9. Inhibition of aggrecanase activity with monoclonal antibodies, tissue inhibitor of metalloproteinases 3 (TIMP-3), and cycloheximide pretreatment were used to identify ADAMTS isoforms involved in IGD-aggrecan catabolism. |
32(0,1,1,2) | Details |