| Name | Jak 2 |
|---|---|
| Synonyms | JAK 2; JAK2; JAK2 protein; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine protein kinase 2; Tyrosine protein kinase JAK2; JAK2 proteins… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17197193 | Fritzenwanger M, Meusel K, Foerster M, Kuethe F, Krack A, Figulla HR: Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells. Cytokine. 2006 Nov;36(3-4):101-6. Epub 2007 Jan 2. For the pathway determination following inhibitors were used: (signal transducer and activation of transcription (STAT) 3 phosphorylation), wortmannin (phosphatiylinositol 3-kinase (PI3K)), SB203580 (p38 mitogen-activated protein kinase (MAPK)), AG490 (Janus kinase (JAK) 2), PD98059 (mitogen-activated protein kinase kinase (MEK) 1/2), parthenolide (nuclear factor kappaB) and cycloheximide (protein biosynthesis). |
32(0,1,1,2) | Details |
| 17488973 | Deng L, He K, Wang X, Yang N, Thangavel C, Jiang J, Fuchs SY, Frank SJ: Determinants of growth hormone receptor down-regulation. Mol Endocrinol. 2007 Jul;21(7):1537-51. Epub 2007 May 8. GH receptor (GHR) is a cytokine receptor family member that responds to GH by activation of the receptor-associated kinase, JAK2 (Janus family of tyrosine kinase 2). We found that JAK2's ability to protect mature GHR from rapid degradation measured in the presence of the protein synthesis inhibitor, cycloheximide, depended on the presence of GHR's Box 1 element and the intact JAK2 FERM (band 4.1/Ezrin/Radixin/Moesin); domain, but not the kinase-like or kinase domains of JAK2. |
8(0,0,0,8) | Details |
| 19006119 | Suh HN, Lee YJ, Han HJ: Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. J Cell Physiol. 2009 Mar;218(3):643-52. Indeed, IL-6 increased GLUT-2 mRNA and protein expression as well as 2-DG uptake, which were blocked by actinomycin D (AD, transcription inhibitor) and cycloheximide (CHX, translation inhibitor). IL-6 increased Janus Kinase (JAK)-2, signal transducer and activator of transcription (STAT)-3 phosphorylation, intracellular Ca (2+) concentration, and PKC phosphorylation. |
2(0,0,0,2) | Details |
| 15721283 | Choi WH, Ji KA, Jeon SB, Yang MS, Kim H, Min KJ, Shong M, Jou I, Joe EH: Anti-inflammatory roles of in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):125-31. Both RA isoforms also reduced IFN-gamma-induced activation of signal transducers and activators of transcription (STAT) 1, STAT3, Janus kinase (JAK) 1, and JAK2. Furthermore, the effect of pre-treated RA was abolished in the presence of cycloheximide, indicating a requirement for de novo protein synthesis. |
1(0,0,0,1) | Details |
| 17264307 | Ratthe C, Pelletier M, Chiasson S, Girard D: Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling. J Leukoc Biol. 2007 May;81(5):1287-96. Epub 2007 Jan 30. The effect of IL-4 on SOCS3 protein expression was increased markedly when the proteasome inhibitor MG132 was added to the cultures, but this was inhibited by cycloheximide, suggesting that SOCS3 is de novo-synthesized in response to IL-4. We also demonstrated that IL-4 induced phosphorylation of Syk, p38, Erk-1/2, JNK, Jak-1, Jak-2, STAT6, and STAT1 and that treatment of cells with the inhibitors SB203580, PD98059, or AG490 reversed the ability of IL-4 to delay neutrophil apoptosis. |
1(0,0,0,1) | Details |
| 16081639 | He K, Loesch K, Cowan JW, Li X, Deng L, Wang X, Jiang J, Frank SJ: Janus kinase 2 enhances the stability of the mature growth hormone receptor. Endocrinology. 2005 Nov;146(11):4755-65. Epub 2005 Aug 4. To address these potential mechanisms, metabolic pulse-chase labeling experiments and experiments in which the fate of previously synthesized GHR was followed by anti-GHR immunoblotting after cycloheximide treatment (cycloheximide chase experiments) were performed. |
6(0,0,0,6) | Details |
| 17761766 | Loesch K, Deng L, Wang X, He K, Jiang J, Frank SJ: Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. Endocrinology. 2007 Dec;148(12):5955-65. Epub 2007 Aug 30. Notably, BFA washout in the presence of cycloheximide blocked both basal remnant and precursor GHR reappearance, but BFA washout in the presence of lactacystin blocked only basal remnant reappearance, suggesting that basal remnant is generated proteasome dependently from precursor GHR. |
5(0,0,0,5) | Details |
| 15666812 | Clark BJ, Li J: Janus kinase 2 signaling in the angiotensin II-dependent activation of StAR expression. Endocr Res. 2004 Nov;30(4):685-93. The Ang II-dependent, but not (Bu) 2cAMP-dependent, induction of StAR mRNA was also blocked by AG490 and shown to be sensitive to cycloheximide treatment. |
1(0,0,0,1) | Details |