Protein Information

Name BTG2
Synonyms B cell translocation gene 2; PC3; BTG 2; BTG2; BTG2 protein; NGF inducible anti proliferative protein PC3; Pheochromocytoma cell 3; TIS21…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19117054 Karmakar S, Foster EA, Smith CL: Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor. Int J Cancer. 2009 Apr 15;124(8):1841-51.

Depletion of ERalpha by siRNA indicated that the receptor is required for E2 down regulation of BTG2 mRNA levels, and cycloheximide experiments indicated that the effect of E2 on BTG2 expression was independent of intermediary protein synthesis.
39(0,1,1,9) Details
15870875 Kwon YK, Jun JM, Shin SW, Cho JW, Suh SI: Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells. Int J Oncol. 2005 Jun;26(6):1597-603.

3(0,0,0,3) Details
18055484 Nogueira EF, Vargas CA, Otis M, Gallo-Payet N, Bollag WB, Rainey WE: Angiotensin-II acute regulation of rapid response genes in human, bovine, and rat adrenocortical cells. J Mol Endocrinol. 2007 Dec;39(6):365-74.

The gene list generated by this comparison included: activating transcription factor 3, B-cell translocation gene (BTG2), Nuclear receptor subfamily 4, group A, member 1 (NR4A1), NR4A2, NR4A3, early growth response 1, v-fos FBJ murine osteosarcoma viral oncogene homolog (c-FOS), FOSB, and Jun family member B (JUNB).
Pretreatment of H295R cells with cycloheximide had no effect on Ang-II induction of these genes, suggesting that they are direct targets of Ang-II signaling.
1(0,0,0,1) Details