Protein Information

Name CD34
Synonyms CD34; CD34 antigen; CD34 molecule; CD34F; HPCA 1; HPCA1; Hematopoietic progenitor cell antigen; Hematopoietic progenitor cell antigen CD34…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
11849228 Peled T, Landau E, Prus E, Treves AJ, Nagler A, Fibach E: Cellular copper content modulates differentiation and self-renewal in cultures of cord blood-derived CD34+ cells. Br J Haematol. 2002 Mar;116(3):655-61.

 4(0,0,0,4) Details
10913369 Pyatt DW, Yang Y, Le A, Stillman WS, Irons RD: Dithiocarbamates inhibit hematopoiesis via a copper-dependent mechanism. . Biochem Biophys Res Commun. 2000 Aug 2;274(2):513-8.

In the present study, we investigated the potential of dimethyl- and diethyl-dithiocarbamate to alter clonogenic response of primary human CD34 (+) bone marrow cells in vitro.
We further demonstrate that the addition of copper sulfate greatly potentiates the hematotoxicity of DTC and that the addition of a copper-specific chelator completely abrogates DTC clonogenic suppression.		 2(0,0,0,2) Details