| Name | thioredoxin |
|---|---|
| Synonyms | ADF; TRX 1; TRX1; ATL derived factor; SASP; Surface associated sulphydryl protein; TRDX; TRX… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15618434 | Tsukamoto S, Morita S, Hirano E, Yokoi H, Masumura T, Tanaka K: A novel cis-element that is responsive to oxidative stress regulates three antioxidant defense genes in rice. Plant Physiol. 2005 Jan;137(1):317-27. Epub 2004 Dec 23. In this study, we found that a 28-bp motif is conserved on the promoter regions of three antioxidant defense genes in rice (Oryza sativa): cytosolic superoxide dismutase (sodCc1), cytosolic thioredoxin (trxh), and glutaredoxin (grx). |
1(0,0,0,1) | Details |
| 12782306 | Tien Nguyen-nhu N, Knoops B: Mitochondrial and cytosolic expression of human peroxiredoxin 5 in Saccharomyces cerevisiae protect yeast cells from oxidative stress induced by paraquat. FEBS Lett. 2003 Jun 5;544(1-3):148-52. Human peroxiredoxin 5 is a recently discovered mitochondrial, peroxisomal and cytosolic thioredoxin peroxidase able to reduce peroxide and alkyl hydroperoxides. |
1(0,0,0,1) | Details |
| 20202476 | Niso-Santano M, Gonzalez-Polo RA, Bravo-San Pedro JM, Gomez-Sanchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Moran JM, Cuadrado A, Fuentes JM: Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis. Free Radic Biol Med. 2010 Mar 2. In a search for a physiological pathway that might counterbalance PQ-induced ASK1 activation, we analyzed the role of the transcription factor Nrf2, master regulator of redox homeostasis, and its target thioredoxin (Trx), which binds and inhibits ASK1. |
1(0,0,0,1) | Details |
| 16328792 | Keryer E, Collin V, Lavergne D, Lemaire S, Issakidis-Bourguet E: Characterization of Arabidopsis Mutants for the Variable Subunit of Ferredoxin:thioredoxin Reductase. Photosynth Res. 2004;79(3):265-74. Our results provide in planta confirmation of the antioxidant role previously proposed for some of the plastidial thioredoxins from Arabidopsis thaliana. Disruptants were found significantly more sensitive to oxidative stress as imposed under high light or in the presence of paraquat. |
1(0,0,0,1) | Details |
| 15618175 | Wang G, Olczak AA, Walton JP, Maier RJ: Contribution of the Helicobacter pylori thiol peroxidase bacterioferritin comigratory protein to oxidative stress resistance and host colonization. Infect Immun. 2005 Jan;73(1):378-84. Compared to the parent strain and the ahpC mutant strain, the bcp mutant showed moderate sensitivity to the -generating agent paraquat and to organic hydroperoxides. Purified BCP was shown to be a thiol peroxidase that depends on the reducing activity of thioredoxin and thioredoxin reductase. |
1(0,0,0,1) | Details |
| 12732627 | Wang X, Phelan SA, Forsman-Semb K, Taylor EF, Petros C, Brown A, Lerner CP, Paigen B: Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003 Jul 4;278(27):25179-90. Epub 2003 May 5. To determine these functions, we generated Prdx6-targeted mutant (Prdx6-/-) mice, confirmed the gene disruption by Southern blots, PCR, RT-PCR, Western blots, and immunohistochemistry, and compared the effects of paraquat, peroxide, and t-butyl hydroperoxide on Prdx6-/- and wild-type (Prdx6+/+) macrophages, and of paraquat on Prdx6-/- and Prdx6+/+ mice. |
0(0,0,0,0) | Details |
| 10366417 | Ejima K, Nanri H, Araki M, Uchida K, Kashimura M, Ikeda M: 17beta- induces protein thiol/disulfide oxidoreductases and protects cultured bovine aortic endothelial cells from oxidative stress. Eur J Endocrinol. 1999 Jun;140(6):608-13. Other sex hormones such as and did not affect the contents of these oxidoreductases in BAECs. (HNE)-protein adducts, which are generated by lipid peroxidation, were accumulated in BAECs exposed to paraquat, whereas the pretreatment of BAECs with 17beta- suppressed their accumulation. |
0(0,0,0,0) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
162(2,2,2,2) | Details |
| 19735704 | Yang W, Tiffany-Castiglioni E, Koh HC, Son IH: Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol Lett. 2009 Dec 15;191(2-3):203-10. Epub 2009 Sep 6. Finally, apoptotic DNA damage by paraquat was investigated and this damage was attenuated by salubrinal (ER stress inhibitor), thioredoxin (ASK1 inhibitor) and SP600125 (JNK inhibitor). |
31(0,1,1,1) | Details |
| 14605796 | Li K, Pasternak C, Klug G: Expression of the trxA gene for thioredoxin 1 in Rhodobacter sphaeroides during oxidative stress. Arch Microbiol. 2003 Dec;180(6):484-9. Epub 2003 Nov 7. A strain expressing lower levels of thioredoxin 1 showed decreased resistance to diamide and H (2) O (2) but increased resistance to paraquat and t-BOOH compared to the wild-type. |
9(0,0,1,4) | Details |
| 17055214 | Takizawa M, Komori K, Tampo Y, Yonaha M: Paraquat-induced oxidative stress and dysfunction of cellular redox systems including antioxidative defense enzymes peroxidase and thioredoxin reductase. Toxicol In Vitro. 2007 Apr;21(3):355-63. Epub 2006 Sep 14. We examined if paraquat-induced oxidative stress and cytotoxicity in pulmonary microvascular endothelial cells are associated with cellular redox systems such as the system and the thioredoxin system. |
6(0,0,1,1) | Details |
| 15530657 | Chen L, Rio DC, Haddad GG, Ma E: Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):93-100. Using dhd [encoding a Drosophila homolog of the mammalian protein thioredoxin (Trx)] transgenic flies, we confirmed that the resistance of dADAR mutant flies to paraquat resulted, at least partially, from the up-regulation of dhd gene in dADAR mutant flies. |
6(0,0,1,1) | Details |
| 10675547 | Broin M, Cuine S, Peltier G, Rey P: Involvement of CDSP 32, a drought-induced thioredoxin, in the response to oxidative stress in potato plants. FEBS Lett. 2000 Feb 11;467(2-3):245-8. |
4(0,0,0,4) | Details |
| 17466556 | Kim YJ, Lee KS, Kim BY, Choo YM, Sohn HD, Jin BR: Thioredoxin from the silkworm, Bombyx mori: cDNA sequence, expression, and functional characterization. Comp Biochem Physiol B Biochem Mol Biol. 2007 Jul;147(3):574-81. Epub 2007 Mar 31. When H2O2 or paraquat was injected into the body cavity of B. mori larvae, BmTrx mRNA expression was upregulated in the fat body tissue. |
3(0,0,0,3) | Details |
| 12954614 | Jurado J, Prieto-Alamo MJ, Madrid-Risquez J, Pueyo C: Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse. J Biol Chem. 2003 Nov 14;278(46):45546-54. Epub 2003 Sep 3. Quantitations reported establish differences among adult organs and embryonic stages, compare mRNA decay rates, explore the significance of alternative mRNA isoforms derived from TrxR1 and Grx2 genes, and examine the time-course expression upon stress promoted by paraquat. |
3(0,0,0,3) | Details |
| 12576586 | Comtois SL, Gidley MD, Kelly DJ: Role of the thioredoxin system and the thiol-peroxidases Tpx and Bcp in mediating resistance to oxidative and nitrosative stress in Helicobacter pylori. Microbiology. 2003 Jan;149(Pt 1):121-9. Mutation of trxA1 led to a pronounced increase in sensitivity to peroxide and the generator paraquat, as well as to the (NO) releasers sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO), consistent with an in vivo role for Trx1 as a reductant for AhpC. |
2(0,0,0,2) | Details |
| 12857815 | Broin M, Rey P: Potato plants lacking the CDSP32 plastidic thioredoxin exhibit overoxidation of the BAS1 2- peroxiredoxin and increased lipid Peroxidation in thylakoids under photooxidative stress. Plant Physiol. 2003 Jul;132(3):1335-43. |
2(0,0,0,2) | Details |
| 18758731 | Song JY, Roe JH: The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe. J Microbiol. 2008 Aug;46(4):408-14. Epub 2008 Aug 31. The Deltatrx1 mutant was found sensitive to diverse external stressors such as various oxidants, heat, and salt, whereas Deltatrx2 mutant was not sensitive except to paraquat, a generator. |
2(0,0,0,2) | Details |
| 12715897 | Missirlis F, Rahlfs S, Dimopoulos N, Bauer H, Becker K, Hilliker A, Phillips JP, Jackle H: A putative peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Biol Chem. 2003 Mar;384(3):463-72. They generate sulfhydryl-reducing systems which are coupled to antioxidant enzymes, the thioredoxin and peroxidases (TPx and GPx). |
2(0,0,0,2) | Details |
| 16024017 | Byun HS, Cho EW, Kim JS, Moon MS, Yum JJ, Kim KC, Kim IG: Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation. FEBS Lett. 2005 Aug 1;579(19):4055-62. TRX-overexpression made HT-1080 cells resistant to an oxidative stress caused by H2O2 or paraquat. |
2(0,0,0,2) | Details |
| 20116453 | Farmen E, Olsvik PA, Berntssen MH, Hylland K, Tollefsen KE: Oxidative stress responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to pro-oxidants and a complex environmental sample. Comp Biochem Physiol C Toxicol Pharmacol. 2010 May;151(4):431-8. Epub 2010 Jan 28. The pro-oxidants CuSO (4) and paraquat were used as models for comparison to a complex environmental sample. Results following 6, 24, 48 and 96h exposure to different concentrations of these substances show cellular effects on intracellular ROS formation, levels and redox status, expression of the antioxidant enzymes superoxide dismutase, catalase, peroxidase, glutathione reductase, gamma-glutamyl- synthetase (GCS) and thioredoxin, as well as cytotoxicity parameters. |
1(0,0,0,1) | Details |
| 10754530 | Suzuki Y, Kondo Y, Himeno S, Nemoto K, Akimoto M, Imura N: Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. METHODS: Three cell lines of human hormone-independent prostate cancer (PC-3, PC-3 MA2, and HPC36M) were examined for activities of superoxide dismutase, catalase, and peroxidase, and for levels of protein and nonprotein thiols such as metallothionein, and thioredoxin. Sensitivity of these cells to anticancer drugs and inducers of reactive species such as paraquat, tert-butylhydroperoxide, and peroxide was determined by microtiter assay. |
1(0,0,0,1) | Details |
| 12663510 | Zhang J, Svehlikova V, Bao Y, Howie AF, Beckett GJ, Williamson G: Synergy between and in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 2003 Mar;24(3):497-503. Thioredoxin reductases (TrxRs) catalyse the -dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. The combination of and Se also efficiently protected HepG2 cells from paraquat-induced cell death, whereas -only and Se-only treatments showed very little if any protective effect. |
1(0,0,0,1) | Details |
| 18755596 | Ahsan N, Lee DG, Lee KW, Alam I, Lee SH, Bahk JD, Lee BH: -induced oxidative stress in rice leaves revealed by proteomic approach. Plant Physiol Biochem. 2008 Dec;46(12):1062-70. Epub 2008 Jul 19. Two-week-old rice leaves were subjected to or a reactive species (ROS) inducing herbicide paraquat, and total soluble proteins were extracted and analyzed by two-dimensional gel electrophoresis (2-DE) coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) analysis. An increased accumulation of antioxidant enzymes including peroxidase, glutathione S-transferase, thioredoxin h-type, nucleoside diphosphate kinase 1, peroxiredoxin and a superoxide dismutase [Cu-Zn] chloroplast precursor in the -treated sample suggests that a treatment possibly generates oxidative stress in plants. |
1(0,0,0,1) | Details |
| 17724847 | Castro-Sowinski S, Matan O, Bonafede P, Okon Y: A thioredoxin of Sinorhizobium meliloti CE52G is required for production and symbiotic fixation. Mol Plant Microbe Interact. 2007 Aug;20(8):986-93. The mutant strain was affected in the response to paraquat-induced oxidative stress, symbiotic fixation, and both laccase and tyrosinase activities. |
2(0,0,0,2) | Details |
| 12556226 | Radyuk SN, Sohal RS, Orr WC: Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Biochem J. 2003 May 1;371(Pt 3):743-52. Overexpression of either one of them in Drosophila S2 cells conferred increased resistance to toxicity induced by peroxide, paraquat or cadmium. |
2(0,0,0,2) | Details |
| 19687198 | Achard ME, Hamilton AJ, Dankowski T, Heras B, Schembri MS, Edwards JL, Jennings MP, McEwan AG: A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae. Infect Immun. 2009 Nov;77(11):4934-9. Epub 2009 Aug 17. Bioinformatics analysis indicated that the predicted NG_TlpA protein contained a cleavable signal peptide at the N terminus, and secondary structure analysis identified a thioredoxin fold with a helical insertion (approximately 25 residues), similar to that found in B. japonicum TlpA but absent in cytoplasmic thioredoxins. A tlpA mutant of N. gonorrhoeae strain 1291 was found to be highly sensitive to oxidative killing by paraquat and peroxide, indicating an antioxidant role for the NG_TlpA in this bacterium. |
2(0,0,0,2) | Details |
| 18588894 | Cai GB, Bae YA, Kim SH, Sohn WM, Lee YS, Jiang MS, Kim TS, Kong Y: Vitellocyte-specific expression of phospholipid hydroperoxide peroxidases in Clonorchis sinensis. Int J Parasitol. 2008 Dec;38(14):1613-23. Epub 2008 Jun 7. Oxidative stimulation of viable worms with H (2) O (2) or paraquat resulted in 1.5- to 2-fold induction of the GPx activity. In the eggs, an electron donor for GPx, was co-localised with the CsGPx proteins, while thioredoxin, which is preferred by peroxiredoxin, was principally detected in the extracellular space between the embryonic cell mass and an eggshell. |
2(0,0,0,2) | Details |