| Name | AP 1 (protein family or complex) |
|---|---|
| Synonyms | AP 1; AP 1 complex; AP1; Adapter related protein complex 1 |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10195331 | Li X, Sun AY: Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells. J Neural Transm. 1999;106(1):1-21. Interestingly, both apoptotic cell death and AP-1/DNA binding activity induced by paraquat were blocked by cyclohexamide and indicating that both the AP-1/DNA binding activation and apoptosis induced by paraquat are closely related. |
81(1,1,1,1) | Details |
| 11728812 | Zhou LZ, Johnson AP, Rando TA: NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic Biol Med. 2001 Dec 1;31(11):1405-16. |
7(0,0,0,7) | Details |
| 17935786 | Olesen BT, Clausen J, Vang O: Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat. Neurotoxicology. 2008 Jan;29(1):13-21. Epub 2007 Sep 1. Paraquat induced the expression of Mn- and CuZn SOD, catalase and decreases the expression of c-jun (a part of AP-1). |
7(0,0,1,2) | Details |
| 10464329 | Wenk J, Brenneisen P, Wlaschek M, Poswig A, Briviba K, Oberley TD, Scharffetter-Kochanek K: Stable overexpression of manganese superoxide dismutase in mitochondria identifies peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1. J Biol Chem. 1999 Sep 3;274(36):25869-76. The Mn-SOD-overexpressing cells revealed specific resistance to the (O-(2))-generating agent paraquat, whereas no resistance to UVA-generated oxidative stress was found. |
2(0,0,0,2) | Details |
| 17048122 | Kinoshita A, Kobayashi D, Saitoh Y, Tanabe N, Uchino K, Nishiguchi K, Okumura K, Komada F: Regulation of exogenous gene expression by . Pharm Res. 2006 Nov;23(11):2536-41. Epub 2006 Oct 18. The cytomegalovirus long terminal repeat (CMV-LTR) has a TPA response element (TRE) as a binding site for activator protein 1 (AP-1), which is induced by oxidative stress. Each type of cell was exposed to radicals using paraquat for 24 h. |
2(0,0,0,2) | Details |
| 17561093 | Dinis-Oliveira RJ, Sousa C, Remiao F, Duarte JA, Ferreira R, Sanchez Navarro A, Bastos ML, Carvalho F: prevents paraquat-induced apoptosis in the rat lung. . Free Radic Biol Med. 2007 Jul 1;43(1):48-61. Epub 2007 Mar 24. The two main caspase cascades (the extrinsic receptor-mediated and the intrinsic mitochondria-mediated) and the expressions of p53 and activator protein-1 (AP-1) were also evaluated, to obtain an insight into apoptotic cellular signaling. |
2(0,0,0,2) | Details |
| 10644010 | Morandini R, Boeynaems JM, Duhant X, Jacquemotte F, Kinnaert E, Ghanem G: SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1053-63. Two of these--NFkappaB and AP-1--can also be activated by reactive species, including the (also produced under TNF challenge). Our results show a 20-50% increase in both SOD activities when cells were exposed to TNF or to an oxidative stress produced by Paraquat (a generator of radicals), both in terms of enzymes activity (zymogram) and protein levels (Western blotting and ELISA). |
1(0,0,0,1) | Details |
| 11485197 | Leisinger U, Rufenacht K, Fischer B, Pesaro M, Spengler A, Zehnder AJ, Eggen RI: The peroxidase homologous gene from Chlamydomonas reinhardtii is transcriptionally up-regulated by singlet Plant Mol Biol. 2001 Jul;46(4):395-408. Within this region a regulatory sequence homologous to the mammalian cAMP response element (CRE) and activator protein 1 (AP-1) binding site was identified within a 16 bp palindrome. In contrast, the Gpxh mRNA levels were only weakly induced by exposure to the -generating compound paraquat and by peroxide. |
1(0,0,0,1) | Details |