| Name | uncoupling protein 2 |
|---|---|
| Synonyms | Mitochondrial uncoupling protein 2; SLC25A8; UCP 2; UCP2; UCPH; UPCH; Uncoupling protein 2; Uncoupling protein 2s |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16054055 | Fridell YW, Sanchez-Blanco A, Silvia BA, Helfand SL: Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metab. 2005 Feb;1(2):145-52. When human UCP2 (hUCP2) is targeted to the mitochondria of adult fly neurons, we find an increase in state 4 respiration, a decrease in ROS production, a decrease in oxidative damage, heightened resistance to the free radical generator paraquat, and an extension in life span without compromising fertility or physical activity. |
32(0,1,1,2) | Details |
| 18687678 | Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS: UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7;283(45):30461-70. Epub 2008 Aug 7. Restoration of the cytosol oxidative state of erythroid progenitor cells by the pro-oxidant Paraquat reversed the effect of UCP2 deficiency on cell proliferation in in vitro differentiation assays. |
13(0,0,1,8) | Details |