| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17509817 | Kang X, Chen J, Xu Z, Li H, Wang B: Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells. Toxicol In Vitro. 2007 Sep;21(6):1003-9. Epub 2007 Feb 21. Moreover, EGb761 pretreatment evidently increased the numbers of tyrosine hydroxylase (TH) positive and bcl-2 positive cells and degraded the number of caspase-3 positive cells in PQ-injured PC12 cells, in comparison to the treatment with PQ alone. |
2(0,0,0,2) | Details |
| 18836921 | Moran JM, Gonzalez-Polo RA, Ortiz-Ortiz MA, Niso-Santano M, Soler G, Fuentes JM: Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J Toxicol Environ Health A. 2008;71(22):1457-67. Our analysis of apoptotic process through microarray technology showed that in PQ-induced neuroblastoma SH-SY5Y cells, there is a different expression of BIK, CASP3, CASP7, CRADD, DAPK, FAS, and other related genes, in comparison to unstimulated cells. |
1(0,0,0,1) | Details |
| 17220179 | Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, Podlutsky A, Csiszar A: increases vascular oxidative stress resistance. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2417-24. Epub 2007 Jan 12. We found that oxidized LDL and TNF-alpha elicited significant increases in caspase-3/7 activity in endothelial cells and cultured rat aortas, which were prevented by pretreatment (10 (-6)-10 (-4) mol/l). Indeed, treatment protected cultured aortic segments and/or endothelial cells against increases in intracellular H (2) O (2) levels and H (2) O (2)-mediated apoptotic cell death induced by oxidative stressors (exogenous H (2) O (2), paraquat, and UV light). |
1(0,0,0,1) | Details |
| 18235974 | Chen P, Li A, Zhang M, He M, Chen Z, Wu X, Zhao C, Wang S, Liang L: Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells. Acta Biochim Biophys Sin. 2008 Feb;40(2):125-32. In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity. |
1(0,0,0,1) | Details |
| 17561093 | Dinis-Oliveira RJ, Sousa C, Remiao F, Duarte JA, Ferreira R, Sanchez Navarro A, Bastos ML, Carvalho F: prevents paraquat-induced apoptosis in the rat lung. . Free Radic Biol Med. 2007 Jul 1;43(1):48-61. Epub 2007 Mar 24. PQ-exposed rats suffered a time-dependent increase of caspase-3 and caspase-8 and a decrease of caspase-1 activities in lungs compared to the control group. |
1(0,0,0,1) | Details |
| 17936647 | Hou RR, Chen JZ, Chen H, Kang XG, Li MG, Wang BR: Neuroprotective effects of (-)- on paraquat-induced apoptosis in PC12 cells. Cell Biol Int. 2008 Jan;32(1):22-30. Epub 2007 Sep 1. The possible mechanism may be associated with maintaining mitochondrial membrane potential, inhibiting caspase-3 activity and downregulating the expression of pro-apoptotic protein Smac in cytosol. |
1(0,0,0,1) | Details |
| 18056701 | Fei Q, McCormack AL, Di Monte DA, Ethell DW: Paraquat neurotoxicity is mediated by a Bak-dependent mechanism. . J Biol Chem. 2008 Feb 8;283(6):3357-64. Epub 2007 Dec 4. PQ induced morphological and biochemical features that were consistent with apoptosis, including dose-dependent cytochrome c release, with subsequent caspase-3 and poly (ADP- polymerase cleavage. |
1(0,0,0,1) | Details |
| 11413228 | Ciriolo MR, Aquilano K, De Martino A, Carri MT, Rotilio G: Differential role of and in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants. J Neurochem. 2001 Jun;77(6):1433-43. Cytochrome c release from mitochondria, caspase 3 activation, p53 up-regulation, p21 cleavage and Bcl-2 modulation, all involved in the apoptotic process, were significantly less altered with respect to untransfected cells. On the other hand, H46R cells were as sensitive as SH-SY5Y cells to puromycin-induced apoptosis; furthermore, they were more susceptible to apoptosis elicited by the -generating drug paraquat and to cell necrosis provoked by t-butyl hydroperoxide. |
1(0,0,0,1) | Details |
| 19735704 | Yang W, Tiffany-Castiglioni E, Koh HC, Son IH: Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol Lett. 2009 Dec 15;191(2-3):203-10. Epub 2009 Sep 6. |
0(0,0,0,0) | Details |
| 17018646 | Ramachandiran S, Hansen JM, Jones DP, Richardson JR, Miller GW: Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol Sci. 2007 Jan;95(1):163-71. Epub 2006 Oct 3. |
112(1,2,2,2) | Details |
| 11369509 | Rossi L, Marchese E, Lombardo MF, Rotilio G, Ciriolo MR: Increased susceptibility of -deficient neuroblastoma cells to oxidative stress-mediated apoptosis. Free Radic Biol Med. 2001 May 15;30(10):1177-87. The mechanism underlying paraquat-triggered apoptosis implies dramatic activation of caspase-3 and induction of the transcription factor p53. |
82(1,1,1,2) | Details |
| 12654481 | Cheng WH, Quimby FW, Lei XG: Impacts of glutathione peroxidase-1 knockout on the protection by injected against the pro-oxidant-induced liver aponecrosis and signaling in -deficient mice. Free Radic Biol Med. 2003 Apr 1;34(7):918-27. The paraquat-mediated gene or protein expression of proapoptotic Bax, Bcl-w, and Bcl-X (S), cell survival/death factors GADD45, MDM2, c-Myc, and caspase-3 was upregulated, but that of antiapoptotic Bcl-2 was downregulated in the GPX1-/- mice vs. the WT mice. |
81(1,1,1,1) | Details |
| 19101702 | Chau KY, Korlipara LV, Cooper JM, Schapira AH: Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by receptors. J Neurol Sci. 2009 Mar 15;278(1-2):44-53. Epub 2008 Dec 21. Cabergoline increased content, reduced free radical production and caspase-3 activation, increased mitochondrial membrane potential and ameliorated cell death in SHSY-5Y cells exposed to paraquat and this action was inhibited in part by D2 receptor blockade. |
31(0,1,1,1) | Details |
| 18365879 | Rio MJ, Velez-Pardo C: Paraquat induces apoptosis in human lymphocytes: protective and rescue effects of cannabinoids and insulin-like growth factor-1. Growth Factors. 2008 Feb;26(1):49-60. Further evaluation included (i) radicals, reflected by nitroblue tetrazolium reduction to formazan, (ii) the production of peroxide, reflected by rhodamine-positive fluorescent cells, (iii) the generation of reflected by dimethylsulfoxide and ( radical) OH scavengers, (iv) activation and/or translocation of NF-kappaB, p53 and c-Jun transcription factors showed by immunocytochemical staining, and by ammonium pyrrolidinedithiocarbamate, pifithrin-alpha and SP600125 inhibition and (V) caspase-3 activation, reflected by caspase Ac-DEVD-cho inhibition. |
3(0,0,0,3) | Details |
| 11181820 | Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH: Dopaminergic cell death induced by MPP (+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem. 2001 Feb;76(4):1010-21. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP (+) (the active metabolite of MPTP), paraquat, dieldrin, and Remarkably, the oxidant treatment alone induced similar sequential molecular events: ROS increase, activation of JNK MAP kinases, activation of the PITSLRE kinase, p110, by both Caspase-1 and Caspase-3-like activities and apoptotic cell death. |
1(0,0,0,1) | Details |
| 15157803 | Gonzalez-Polo RA, Rodriguez-Martin A, Moran JM, Niso M, Soler G, Fuentes JM: Paraquat-induced apoptotic cell death in cerebellar granule cells. Brain Res. 2004 Jun 18;1011(2):170-6. Exposure of cerebellar granule cells to relatively low concentrations of paraquat (5 microM) produces apoptotic cell death with a reduction in mitochondrial cytochrome c content, proteolytic activation and caspase-3 activity increase and DNA fragmentation. |
31(0,1,1,1) | Details |
| 15155744 | Peng J, Mao XO, Stevenson FF, Hsu M, Andersen JK: The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem. 2004 Jul 30;279(31):32626-32. Epub 2004 May 20. Our data show that paraquat induces the sequential phosphorylation of c-Jun N-terminal kinase (JNK) and c-Jun and the activation of caspase-3 and sequential neuronal death both in vitro and in vivo. |
31(0,1,1,1) | Details |