| Name | Ang II |
|---|---|
| Synonyms | AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20035857 | Tung JN, Lang YD, Wang LF, Chen CM: Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts. Toxicol In Vitro. 2010 Apr;24(3):803-8. Epub 2009 Dec 24. Angiotensin (ANG) II may induce CTGF expression in the heart and kidney and plays an important role in the pathogenesis of lung fibrosis. |
1(0,0,0,1) | Details |
| 20228935 | Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N: Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY). 2009 Dec 10;2(1):43-62. Here we show that locally acting mIGF-1 increases SirT1 expression/activity, whereas circulating IGF-1 isoform does not affect it, in cultured HL-1 and neonatal cardiomyocytes. mIGF-1-induced SirT1 activity exerts protection against angiotensin II (Ang II)-triggered hypertrophy and against paraquat (PQ) and Ang II-induced oxidative stress. |
0(0,0,0,0) | Details |
| 20226207 | Ribeiro FC, Coimbra CC, Machado MD, Fontes MA: Evidence that central action of paraquat interferes in the dipsogenic effect of Ang II. Neurotoxicology. 2010 Mar 10. |
199(2,3,4,4) | Details |
| 16182431 | Chen CM, Chou HC, Hsu HH, Wang LF: Transforming growth factor-beta1 upregulation is independent of angiotensin in paraquat-induced lung fibrosis. Toxicology. 2005 Dec 15;216(2-3):181-7. Epub 2005 Sep 22. On days 1, 3, 7, and 21 after paraquat treatment, TGF-beta1 and collagen gene expressions, TGF-beta1 protein, angiotensin-converting enzyme (ACE) activity, Ang II, and contents were measured in lung tissue. |
87(1,1,2,2) | Details |
| 15297733 | Orito K, Suzuki Y, Matsuda H, Shirai M, Akahori F: Chymase is activated in the pulmonary inflammation and fibrosis induced by paraquat in hamsters. Tohoku J Exp Med. 2004 Aug;203(4):287-94. In the present study, we examined whether chymase and angiotensin converting enzyme (ACE), that also generates Ang II, were activated in the pulmonary inflammation and fibrosis induced by paraquat (PQ) in hamsters. |
82(1,1,1,2) | Details |
| 19542013 | Figtree GA, Liu CC, Bibert S, Hamilton EJ, Garcia A, White CN, Chia KK, Cornelius F, Geering K, Rasmussen HH: Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation. Circ Res. 2009 Jul 17;105(2):185-93. Epub 2009 Jun 18. Angiotensin II (Ang II) inhibits the cardiac sarcolemmal Na (+)-K (+) pump via protein kinase (PK) C-dependent activation of oxidase. We detected glutathionylation of beta (1), but not alpha (1), subunits in rabbit ventricular myocytes at baseline. beta (1) Subunit glutathionylation was increased by (ONOO (-)), paraquat, or activation of oxidase by Ang II. |
1(0,0,0,1) | Details |
| 19969051 | Lang YD, Chang SF, Wang LF, Chen CM: Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett. 2010 Mar 1;193(1):19-25. Epub 2009 Dec 5. Furthermore, paraquat enhanced Ang II and collagen type I mRNA and protein expression, alpha-smooth muscle actin, and chymase protein and chymase small interfering RNA inhibited these effects. |
44(0,1,3,4) | Details |
| 16458281 | Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M: ameliorates paraquat-induced lung fibrosis. . Clin Chim Acta. 2006 May;367(1-2):170-4. Epub 2006 Feb 3. The antifibrotic effect of has shown to be due to inhibition of synthesis of angiotensin II that causes stimulation of fibroblast proliferation and collagen synthesis. |
2(0,0,0,2) | Details |