| Name | LRRK2 |
|---|---|
| Synonyms | Dardarin; LRRK 2; LRRK2; Leucine rich repeat kinase 2; Leucine rich repeat serine/threonine protein kinase 2; PARK 8; PARK8; Parkinson disease (autosomal dominant) 8… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19625511 | Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B: LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci. 2009 Jul 22;29(29):9210-8. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are agents that cause mitochondrial dysfunction. |
14(0,0,1,9) | Details |
| 18257932 | Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z: Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener. 2008 Feb 8;3:3. However, dLRRK mutant flies were selectively sensitive to peroxide induced stress but not to paraquat, rotenone and beta-mercaptoethanol induced stresses. |
6(0,0,0,6) | Details |
| 19251702 | Samann J, Hegermann J, von Gromoff E, Eimer S, Baumeister R, Schmidt E: Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem. 2009 Jun 12;284(24):16482-91. Epub 2009 Feb 27. Mutations in two genes encoding the putative kinases LRRK2 and PINK1 have been associated with inherited variants of Parkinson disease. Here, we show that a mutation in the Caenorhabditits elegans homologue of the PTEN-induced kinase pink-1 gene resulted in reduced mitochondrial cristae length and increased paraquat sensitivity of the nematode. |
4(0,0,0,4) | Details |
| 16815551 | Dinis-Oliveira RJ, Remiao F, Carmo H, Duarte JA, Navarro AS, Bastos ML, Carvalho F: Paraquat exposure as an etiological factor of Parkinson's disease. Neurotoxicology. 2006 Dec;27(6):1110-22. Epub 2006 Jul 3. The role of genetic predisposition in PD has been increasingly acknowledged and a number of relevant genes have been identified (e.g., genes encoding alpha-synuclein, parkin, and dardarin), while the search for environmental factors that influence the pathogenesis of PD has only recently begun to escalate. |
1(0,0,0,1) | Details |