Protein Information

Name c Cbl
Synonyms C CBL; CBL; CBL 2; CBL2; Cas Br M (murine) ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; E3 ubiquitin protein ligase CBL; Proto oncogene c CBL…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
17298174 Li Z, Dong T, Proschel C, Noble M: Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol. 2007 Feb;5(2):e35.

Sequential Fyn and c-Cbl activation, with consequent pathway-specific suppression of RTK signaling, is induced by levels of methylmercury and lead that affect large segments of the population, as well as by paraquat, an organic herbicide.
34(0,1,1,4) Details