| Name | Iron regulatory protein 1 |
|---|---|
| Synonyms | ACO 1; ACO1; Aconitase; Aconitase 1; Aconitase 1 variant; Aconitate hydratase; Citrate hydro lyase; Ferritin repressor protein… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17469137 | Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. Using the AF5 neural-derived cell line, which displays GABAergic properties, we showed that Mn significantly increased release to 174%-214% of that of the control and that the effects of Mn exposure on the metabolism of and resembled the effects of fluorocitrate, an inhibitor of aconitase, but not the effects of other toxicants including paraquat, rotenone, or 3-nitropropionic acid. RNA mobility shift assay and Western blot showed that Mn treatment caused c-aconitase to be converted to iron regulatory protein 1 (IRP1) and increased the abundance of IRP2, leading to reduced H-ferritin expression, increased transferrin receptor expression, and increased uptake of transferrin. |
3(0,0,0,3) | Details |
| 12972424 | Missirlis F, Hu J, Kirby K, Hilliker AJ, Rouault TA, Phillips JP: Compartment-specific protection of iron- proteins by superoxide dismutase. J Biol Chem. 2003 Nov 28;278(48):47365-9. Epub 2003 Sep 12. We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iron and oxidative stress through its labile iron cluster by switching between cytosolic aconitase and RNA-binding functions. We also find that exposure of adults to paraquat converts cytosolic aconitase to IRP1 but has no affect on mitochondrial aconitase, indicating that paraquat generates in the cytosol but not in mitochondria. |
2(0,0,0,2) | Details |
| 15664434 | Ayaki H, Lee MJ, Sumino K, Nishio H: Different cytoprotective effect of antioxidants and change in the iron regulatory system in rodent cells exposed to paraquat or Toxicology. 2005 Mar 1;208(1):73-9. Paraquat induced a time-dependent increase in the binding of iron regulatory protein 1 (IRP1) to iron-responsive element (IRE), and the enhanced IRP1 activity continued over 24 h. |
81(1,1,1,1) | Details |
| 11098297 | Konstantinova SG, Russanov EM: Studies on paraquat-induced oxidative stress in rat liver. . Acta Physiol Pharmacol Bulg. 1999;24(4):107-11. The results cast additional light on the responses of both aconitases to oxidative stress. |
1(0,0,0,1) | Details |