Protein Information

Name Apolipoprotein D
Synonyms APOD; ASOB 2; ASOB2; Apo D; ApoD; Apolipoprotein D; Apolipoprotein D precursor; Apo Ds…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
18458334 Muffat J, Walker DW, Benzer S: Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7088-93. Epub 2008 May 5.

We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress conditions associated with aging and neurodegeneration, including hyperoxia, dietary paraquat, and heat stress.
10(0,0,1,5) Details
18419796 Ganfornina MD, Do Carmo S, Lora JM, Torres-Schumann S, Vogel M, Allhorn M, Gonzalez C, Bastiani MJ, Rassart E, Sanchez D: Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008 Aug;7(4):506-15. Epub 2008 Apr 14.

7(0,0,0,7) Details
16581513 Sanchez D, Lopez-Arias B, Torroja L, Canal I, Wang X, Bastiani MJ, Ganfornina MD: Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol. 2006 Apr 4;16(7):680-6.

Apoptotic neural cell death increases in aged flies or upon paraquat treatment, which also impairs neural function as assessed by behavioral tests.
5(0,0,0,5) Details
18671872 Charron JB, Ouellet F, Houde M, Sarhan F: The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress. BMC Plant Biol. 2008 Jul 31;8:86.

AtTIL knock-out plants are very sensitive to sudden drops in temperature and paraquat treatment, and dark-grown plants die shortly after transfer to light.
3(0,0,0,3) Details