Protein Information

Name Prohibitin
Synonyms PHB; Prohibitin; Prohibitins

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
16640602 Ahn CS, Lee JH, Reum Hwang A, Kim WT, Pai HS: Prohibitin is involved in mitochondrial biogenesis in plants. Plant J. 2006 May;46(4):658-67.

Finally, disruption of prohibitin function rendered the plants more susceptible to various oxidative stress-inducing reagents, including H (2) O (2), paraquat, antimycin A and salicylic acid.
36(0,1,1,6) Details
17030995 Malavazi I, Savoldi M, Di Mauro SM, Menck CF, Harris SD, Goldman MH, Goldman GH: Transcriptome analysis of Aspergillus nidulans exposed to camptothecin-induced DNA damage. Eukaryot Cell. 2006 Oct;5(10):1688-704.

We characterized six genes that have increased mRNA expression in the presence of CPT in the wild-type strain relative to the uvsB (ATR) mutant strain: fhdA (encoding a forkhead-associated domain protein), tprA (encoding a hypothetical protein that contains a tetratrico peptide repeat), mshA (encoding a MutS homologue involved in mismatch repair), phbA (encoding a prohibitin homologue), uvsC (RAD51) (the homologue of the RAD51 gene), and cshA (encoding a homologue of the excision repair protein ERCC-6 [Cockayne's syndrome protein]).
Moreover, with the exception of UvsC, deletion of each of these genes partially suppressed the sensitivity of the DeltauvsB strain to menadione and paraquat.
1(0,0,0,1) Details