| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17535659 | Jian XD, Sui H, Chu ZH, Zhang ZW, Kan BT, Zhang L, Zhang HT: [Changes of serum cytokine caused by acute paraquat poisoning] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Apr;25(4):230-2. OBJECTIVE: To observe the change of cytokine interleukin IL-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) occurred in acute paraquat (PQ) poisoning rats and to investigate the mechanism of acute lung injury caused by paraquat (PQ) poisoning. |
31(0,1,1,1) | Details |
| 14759608 | Chen X, Liang H, Van Remmen H, Vijg J, Richardson A: Catalase transgenic mice: characterization and sensitivity to oxidative stress. Arch Biochem Biophys. 2004 Feb 15;422(2):197-210. Hepatocytes and fibroblasts from the Tg (CAT)(+/+) mice were more resistant to peroxide-induced cell death but were more sensitive to paraquat and TNFalpha toxicity. |
6(0,0,1,1) | Details |
| 18308429 | Chen H, Liu B, Lukas TJ, Suyeoka G, Wu G, Neufeld AH: Changes in iron-regulatory proteins in the aged rodent neural retina. . Neurobiol Aging. 2009 Nov;30(11):1865-76. Epub 2008 Mar 4. Exposure of RGC-5 cells to increased iron potentiated the neurotoxicity induced by paraquat, and TNFalpha. |
6(0,0,1,1) | Details |
| 10910079 | Siemankowski LM, Morreale J, Butts BD, Briehl MM: Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD (P) H:quinone reductase. Cancer Res. 2000 Jul 1;60(13):3638-44. This increased sensitivity could not be explained by changes in superoxide dismutase or catalase activity or to increased sensitivity to oxidative stress in general, as assessed by response to peroxide and paraquat treatment. |
2(0,0,0,2) | Details |
| 11292737 | Yamamoto T, Sashinami H, Takaya A, Tomoyasu T, Matsui H, Kikuchi Y, Hanawa T, Kamiya S, Nakane A: Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha. Infect Immun. 2001 May;69(5):3164-74. An -dependent killing assay using peroxide and paraquat (a generator) and a serum killing assay using murine serum demonstrated that all of the serovar Typhimurium Delta clpP and Delta clpX mutants were as resistant to these killing mechanisms as the wild-type strain. |
1(0,0,0,1) | Details |
| 12504350 | Whitehead GS, Grasman KA, Kimmel EC: Lung function and airway inflammation in rats following exposure to combustion products of carbon-graphite/epoxy composite material: comparison to a rodent model of acute lung injury. Toxicology. 2003 Feb 1;183(1-3):175-97. Pulmonary function and inflammation in the lungs of rodents exposed by inhalation to carbon/graphite/epoxy advanced composite material (ACM) combustion products were compared to that of a rodent model of acute lung injury (ALI) produced by pneumotoxic paraquat dichloride. We examined the time-course for mechanical lung function, infiltration of inflammatory cells into the lung, and the expression of three inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2) and interferon-gamma (IFN-gamma). |
1(0,0,0,1) | Details |
| 19497220 | He XY, Sun Q, Li ZW, Lu ZQ, Hong GL, Liang H, Qiu QM, Hu GX: [Expression of inflammatory factors in lung tissue of acute paraquat poisoned rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Mar;27(3):149-52. The level of tumor necrosis factor alpha (TNF-alpha) mRNA, interleukin 10 (IL-10) mRNA, high mobility group box 1 (HMGB-1) mRNA in lung of rats were detected. |
1(0,0,0,1) | Details |
| 17893043 | Ho YS, Xiong Y, Ho DS, Gao J, Chua BH, Pai H, Mieyal JJ: Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic Biol Med. 2007 Nov 1;43(9):1299-312. Epub 2007 Aug 6. In contrast, mouse embryonic fibroblasts (MEFs) isolated from Grx1-deficient mice displayed an increased vulnerability to diquat and paraquat, but they were not more susceptible to cell death induced by peroxide (H (2) O (2)) and diamide. Additional experiments showed that MEFs lacking Grx1 were more tolerant to apoptosis induced by tumor necrosis factor alphaplus actinomycin D. |
1(0,0,0,1) | Details |
| 18187236 | Mangano EN, Hayley S: Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration. Neurobiol Aging. 2009 Sep;30(9):1361-78. Epub 2008 Jan 10. Circulating levels of the inflammatory cytokines, interleukin (IL)-6, IL-2, tumor necrosis factor-alpha and interferon-gamma were also time-dependently elevated following intra-SNc LPS infusion. |
1(0,0,0,1) | Details |
| 15162845 | Takeyama N, Tanaka T, Yabuki T, Nakatani T: The involvement of p53 in paraquat-induced apoptosis in human lung epithelial-like cells. Int J Toxicol. 2004 Jan-Feb;23(1):33-40. U937 and L132 cells die normally with similar kinetics when exposed to tumor necrosis factor in the presence of cycloheximide, indicating that their capacity to undergo p53-independent mechanisms of inducing apoptosis has an equal rate. |
1(0,0,0,1) | Details |
| 16324872 | Ishida Y, Takayasu T, Kimura A, Hayashi T, Kakimoto N, Miyashita T, Kondo T: Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg Med. 2006 Mar;8(2):102-9. Epub 2005 Dec 1. Semi-quantitative RT-PCR analysis demonstrated that the gene expression of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 were significantly increased at 3 weeks after PQ challenge compared with the controls. |
1(0,0,0,1) | Details |
| 20095326 | Huang M, Zhang P, Chang XL, Gu XA, Wu Q, Zhou ZJ: [Changes of cytokine and nuclear factor-kappa B in acute paraquat poisoned rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Aug;27(8):463-7. On the 1st, the 3rd, the 7th, the 14th, the 28th and the 56th day after treatment, the level of interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta 1 (TGF-beta1) and platelet-derived growth factor (PDGF) in serum were detected; the activity of NF-kappaB in lung tissues was detected. |
1(0,0,0,1) | Details |
| 19362168 | Schuller-Levis G, Gordon RE, Wang C, Park SY, Park E: Protection of bleomycin-induced fibrosis and inflammation by . Int Immunopharmacol. 2009 Jul;9(7-8):971-7. Epub 2009 Apr 9. has been shown to protect against lung injury induced by various oxidants including ozone, amiodarone, and paraquat and to protect against bleomycin-induced lung injury in combination with Tumor necrosis factor-alpha (TNF-alpha) as measured by immunohistochemical staining, was present in lungs of both -treated and untreated rats, but was more abundant in the BW group compared to the BT group. |
1(0,0,0,1) | Details |
| 19567158 | Shang Y, Xu SP, Wu Y, Jiang YX, Wu ZY, Yuan SY, Yao SL: reduces acute lung injury in endotoxemic rats. Chin Med J. 2009 Jun 20;122(12):1388-93. BACKGROUND: Treatment with significantly reduces lung injury induced by bleomycin, paraquat and ischemia reperfusion. Wet/dry ratios (W/D), myeloperoxidase activity, malondialdehyde concentrations and tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) levels in lungs were measured. |
1(0,0,0,1) | Details |
| 18977442 | Liu B, Suyeoka G, Papa S, Franzoso G, Neufeld AH: Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries. Neurobiol Dis. 2009 Jan;33(1):104-10. Epub 2008 Oct 14. Using Gadd45b siRNA, we show that Gadd45b protects RGCs from dying against different neuronal injuries including oxidative stress, TNFalpha cytotoxicity, and excitotoxicity in vitro. |
1(0,0,0,1) | Details |
| 15890010 | Wu XF, Block ML, Zhang W, Qin L, Wilson B, Zhang WQ, Veronesi B, Hong JS: The role of microglia in paraquat-induced dopaminergic neurotoxicity. Antioxid Redox Signal. 2005 May-Jun;7(5-6):654-61. |
0(0,0,0,0) | Details |
| 11264896 | Tomita M, Okuyama T, Ishikawa T, Hidaka K, Nohno T: The role of in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line. Free Radic Res. 2001 Feb;34(2):193-202. |
0(0,0,0,0) | Details |