Protein Information

Name neutral amino acid transporter
Synonyms ASCT 1; ASCT1; Alanine/serine/cysteine/ threonine transporter; Neutral amino acid transporter; Neutral amino acid transporter A; SATT; SLC1A4; Alanine/serine/cysteine/ threonine transporters…

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
12641729 McCormack AL, Di Monte DA: Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J Neurochem. 2003 Apr;85(1):82-6.

The purpose of this study was to assess mechanisms of paraquat entry into the CNS and, in particular, the effects of substrates of the blood-brain barrier (BBB) neutral amino acid transporter (System L carrier) on paraquat accumulation and neurotoxicity.
81(1,1,1,1) Details
11430870 Shimizu K, Ohtaki K, Matsubara K, Aoyama K, Uezono T, Saito O, Suno M, Ogawa K, Hayase N, Kimura K, Shiono H: Carrier-mediated processes in blood--brain barrier penetration and neural uptake of paraquat. Brain Res. 2001 Jul 6;906(1-2):135-42.

The pre-treatment of L-valine, which is a high affinity substrate for the neutral amino acid transporter, markedly reduced the BBB penetration of paraquat.
81(1,1,1,1) Details