| Name | peroxiredoxin 6 |
|---|---|
| Synonyms | 1 Cys PRX; PRDX 6; PRDX6; 1 Cys; 1 Cys peroxiredoxin; 24 kDa protein; AOP 2; AOP2… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15890616 | Manevich Y, Fisher AB: Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Radic Biol Med. 2005 Jun 1;38(11):1422-32. Adenoviral-mediated overexpression of Prdx6 in mouse lungs protected against the toxicity of hyperoxia, whereas Prdx6-null mice were more sensitive to the effects of hyperoxia or paraquat. |
2(0,0,0,2) | Details |
| 16487056 | Wang Y, Feinstein SI, Manevich Y, Ho YS, Fisher AB: Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress. Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):229-37. |
87(1,1,2,2) | Details |
| 12732627 | Wang X, Phelan SA, Forsman-Semb K, Taylor EF, Petros C, Brown A, Lerner CP, Paigen B: Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem. 2003 Jul 4;278(27):25179-90. Epub 2003 May 5. To determine these functions, we generated Prdx6-targeted mutant (Prdx6-/-) mice, confirmed the gene disruption by Southern blots, PCR, RT-PCR, Western blots, and immunohistochemistry, and compared the effects of paraquat, peroxide, and t-butyl hydroperoxide on Prdx6-/- and wild-type (Prdx6+/+) macrophages, and of paraquat on Prdx6-/- and Prdx6+/+ mice. |
4(0,0,0,4) | Details |
| 14526116 | Haslekas C, Viken MK, Grini PE, Nygaard V, Nordgard SH, Meza TJ, Aalen RB: Seed 1- peroxiredoxin antioxidants are not involved in dormancy, but contribute to inhibition of germination during stress. Plant Physiol. 2003 Nov;133(3):1148-57. Epub 2003 Oct 2. In plants, the 1-Cys Prxs are highly expressed during late seed development, and the expression pattern is dormancy related in mature seeds. |
4(0,0,0,4) | Details |
| 12851211 | Kim HS, Manevich Y, Feinstein SI, Pak JH, Ho YS, Fisher AB: Induction of 1-cys peroxiredoxin expression by oxidative stress in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Aug;285(2):L363-9. We studied changes in 1-cysPrx expression in rat lungs and lung cell lines in response to oxidative stress due to hyperoxia, H2O2, or paraquat. |
2(0,0,0,2) | Details |
| 19562038 | Trudel S, Kelly M, Fritsch J, Nguyen-Khoa T, Therond P, Couturier M, Dadlez M, Debski J, Touqui L, Vallee B, Ollero M, Edelman A, Brouillard F: Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge. PLoS One. 2009 Jun 29;4(6):e6075. The aim of the current study was to investigate the cellular levels of reactive species (ROS), oxidative damage and enzymatic antioxidant defenses in the lung of Cftr-knockout mice in basal conditions and as a response to oxidative insult.The results show that endogenous ROS and lipid peroxidation levels are higher in Cftr (-/-) lung when compared to wild-type (Cftr (+/+)) in basal conditions, despite a strong enzymatic antioxidant response involving superoxide dismutases, peroxidases and peroxiredoxin 6 (Prdx6). A dramatic increase in PL-OOH levels in Cftr (-/-) lung consecutive to in vivo oxidative challenge by paraquat (PQ) unmasks a susceptibility to phospholipid peroxidation. |
1(0,0,0,1) | Details |