| Name | PINK1 |
|---|---|
| Synonyms | BRPK; PARK6; PARK 6; PINK 1; PINK1; PTEN induced putative kinase 1; PTEN induced putative kinase protein 1; PTEN induced putative kinase 1s… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19251702 | Samann J, Hegermann J, von Gromoff E, Eimer S, Baumeister R, Schmidt E: Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem. 2009 Jun 12;284(24):16482-91. Epub 2009 Feb 27. Here, we show that a mutation in the Caenorhabditits elegans homologue of the PTEN-induced kinase pink-1 gene resulted in reduced mitochondrial cristae length and increased paraquat sensitivity of the nematode. |
88(1,1,1,8) | Details |
| 19270741 | Gegg ME, Cooper JM, Schapira AH, Taanman JW: Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. PLoS One. 2009;4(3):e4756. Epub 2009 Mar 9. This mitochondrial dysfunction resulted in increased markers of oxidative stress under basal conditions and increased cell death following treatment with the free radical generator paraquat. |
6(0,0,0,6) | Details |
| 18715146 | Ethell DW, Fei Q: Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal. 2009 Mar;11(3):529-40. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through members of the Bcl-2 family. Of the familial mutations identified thus far, two of the loci encode proteins associated with ubiquitin-proteasome degradation of misfolded proteins (Parkin and Uch-L1), and two encode proteins associated with mitochondria and oxidative stress (DJ-1 and PINK1). |
1(0,0,0,1) | Details |
| 19500570 | Grunewald A, Gegg ME, Taanman JW, King RH, Kock N, Klein C, Schapira AH: Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology. Exp Neurol. 2009 Sep;219(1):266-73. Epub 2009 Jun 3. There were increased basal levels of mitochondrial superoxide dismutase in these cells and an exaggerated increase of in response to paraquat-induced free radical formation. |
5(0,0,0,5) | Details |
| 17010972 | Liang CL, Wang TT, Luby-Phelps K, German DC: Mitochondria mass is low in mouse substantia nigra neurons: implications for Parkinson's disease. Exp Neurol. 2007 Feb;203(2):370-80. Epub 2006 Sep 28. Many sporadic PD patients have a defect in mitochondria respiration, and some of the genes that cause PD are mitochondrial-related (e.g., PINK1, Parkin, DJ1). |
1(0,0,0,1) | Details |