| Name | c jun |
|---|---|
| Synonyms | AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11728812 | Zhou LZ, Johnson AP, Rando TA: NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic Biol Med. 2001 Dec 1;31(11):1405-16. The major component of the AP-1 complexes was a heterodimer composed of c-jun/fos. |
1(0,0,0,1) | Details |
| 10464329 | Wenk J, Brenneisen P, Wlaschek M, Poswig A, Briviba K, Oberley TD, Scharffetter-Kochanek K: Stable overexpression of manganese superoxide dismutase in mitochondria identifies peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1. J Biol Chem. 1999 Sep 3;274(36):25869-76. The Mn-SOD-overexpressing cells revealed specific resistance to the (O-(2))-generating agent paraquat, whereas no resistance to UVA-generated oxidative stress was found. Furthermore, prooxidant conditions led to a strong induction of c-jun and c-fos mRNA levels resulting in a 4-fold higher transactivation of the transcription factor AP-1 in the Mn-SOD-overexpressing cells. |
1(0,0,0,1) | Details |
| 11485197 | Leisinger U, Rufenacht K, Fischer B, Pesaro M, Spengler A, Zehnder AJ, Eggen RI: The peroxidase homologous gene from Chlamydomonas reinhardtii is transcriptionally up-regulated by singlet Plant Mol Biol. 2001 Jul;46(4):395-408. Within this region a regulatory sequence homologous to the mammalian cAMP response element (CRE) and activator protein 1 (AP-1) binding site was identified within a 16 bp palindrome. In contrast, the Gpxh mRNA levels were only weakly induced by exposure to the -generating compound paraquat and by peroxide. |
1(0,0,0,1) | Details |
| 17561093 | Dinis-Oliveira RJ, Sousa C, Remiao F, Duarte JA, Ferreira R, Sanchez Navarro A, Bastos ML, Carvalho F: prevents paraquat-induced apoptosis in the rat lung. . Free Radic Biol Med. 2007 Jul 1;43(1):48-61. Epub 2007 Mar 24. The two main caspase cascades (the extrinsic receptor-mediated and the intrinsic mitochondria-mediated) and the expressions of p53 and activator protein-1 (AP-1) were also evaluated, to obtain an insight into apoptotic cellular signaling. |
1(0,0,0,1) | Details |
| 17324951 | Klintworth H, Newhouse K, Li T, Choi WS, Faigle R, Xia Z: Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicol Sci. 2007 May;97(1):149-62. Epub 2007 Feb 25. |
162(2,2,2,2) | Details |
| 16317028 | Liu H, Zheng F, Cao Q, Ren B, Zhu L, Striker G, Vlassara H: Amelioration of oxidant stress by the defensin lysozyme. . Am J Physiol Endocrinol Metab. 2006 May;290(5):E824-32. Epub 2005 Nov 29. LZ also ameliorated paraquat-enhanced cell apoptosis in a dose-dependent manner and suppressed AGE-induced p66 (Shc) expression and c-Jun phosphorylation in Hep G2 cells. |
82(1,1,1,2) | Details |
| 10195331 | Li X, Sun AY: Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells. J Neural Transm. 1999;106(1):1-21. |
81(1,1,1,1) | Details |
| 15155744 | Peng J, Mao XO, Stevenson FF, Hsu M, Andersen JK: The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem. 2004 Jul 30;279(31):32626-32. Epub 2004 May 20. Our data show that paraquat induces the sequential phosphorylation of c-Jun N-terminal kinase (JNK) and c-Jun and the activation of caspase-3 and sequential neuronal death both in vitro and in vivo. |
81(1,1,1,1) | Details |
| 19080378 | Liu JH, Sun ZP, Ma YT: [Change of JNK and c-Jun in lung injury associated with paraquat poisoning of rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 Jul;26(7):406-9. |
15(0,0,2,5) | Details |
| 17935786 | Olesen BT, Clausen J, Vang O: Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat. Neurotoxicology. 2008 Jan;29(1):13-21. Epub 2007 Sep 1. Paraquat induced the expression of Mn- and CuZn SOD, catalase and decreases the expression of c-jun (a part of AP-1). |
6(0,0,1,1) | Details |
| 17048122 | Kinoshita A, Kobayashi D, Saitoh Y, Tanabe N, Uchino K, Nishiguchi K, Okumura K, Komada F: Regulation of exogenous gene expression by . Pharm Res. 2006 Nov;23(11):2536-41. Epub 2006 Oct 18. The cytomegalovirus long terminal repeat (CMV-LTR) has a TPA response element (TRE) as a binding site for activator protein 1 (AP-1), which is induced by oxidative stress. Each type of cell was exposed to radicals using paraquat for 24 h. |
4(0,0,0,4) | Details |
| 18365879 | Rio MJ, Velez-Pardo C: Paraquat induces apoptosis in human lymphocytes: protective and rescue effects of cannabinoids and insulin-like growth factor-1. Growth Factors. 2008 Feb;26(1):49-60. Further evaluation included (i) radicals, reflected by nitroblue tetrazolium reduction to formazan, (ii) the production of peroxide, reflected by rhodamine-positive fluorescent cells, (iii) the generation of reflected by dimethylsulfoxide and ( radical) OH scavengers, (iv) activation and/or translocation of NF-kappaB, p53 and c-Jun transcription factors showed by immunocytochemical staining, and by ammonium pyrrolidinedithiocarbamate, pifithrin-alpha and SP600125 inhibition and (V) caspase-3 activation, reflected by caspase Ac-DEVD-cho inhibition. |
2(0,0,0,2) | Details |