| Name | GADD45 |
|---|---|
| Synonyms | DDIT 1; DDIT1; DNA damage inducible gene GADD45; DNA damage inducible transcript 1; GADD45; GADD45A; Growth arrest and DNA damage inducible gene GADD45 alpha; Growth arrest and DNA damage inducible protein GADD45 alpha… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12654481 | Cheng WH, Quimby FW, Lei XG: Impacts of glutathione peroxidase-1 knockout on the protection by injected against the pro-oxidant-induced liver aponecrosis and signaling in -deficient mice. Free Radic Biol Med. 2003 Apr 1;34(7):918-27. The paraquat-mediated gene or protein expression of proapoptotic Bax, Bcl-w, and Bcl-X (S), cell survival/death factors GADD45, MDM2, c-Myc, and caspase-3 was upregulated, but that of antiapoptotic Bcl-2 was downregulated in the GPX1-/- mice vs. the WT mice. |
81(1,1,1,1) | Details |
| 12595580 | Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA: Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. Physiol Genomics. 2003 Apr 16;13(2):119-27. To investigate the transcriptional response to oxidative stress in the heart and how it changes with age, we examined the cardiac gene expression profiles of young (5-mo-old), middle-aged (15-mo-old), and old (25-mo-old) C57BL/6 mice treated with a single intraperitoneal injection of paraquat (50 mg/kg). Interestingly, only young mice displayed a significant increase in expression of all three isoforms of GADD45, a DNA damage-responsive gene. |
1(0,0,0,1) | Details |
| 15246999 | Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA: Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Ann N Y Acad Sci. 2004 Jun;1019:85-95. To investigate the transcriptional response to oxidative stress in the heart and how it changes with age, we examined the cardiac gene expression profiles of young (5 months old), middle-aged (15 months old), and old (25 months old) C57BL/6 mice treated with a single intraperitoneal injection of paraquat (50 mg/kg). Interestingly, only young mice displayed a significant increase in expression of all three isoforms of GADD45, a DNA damage-responsive gene. |
1(0,0,0,1) | Details |