| Name | p66shc |
|---|---|
| Synonyms | SH2 domain protein C1; P66; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHC 1; SHC transforming protein 1; SHC1; SHCA… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16972253 | Wu Z, Rogers B, Kachi S, Hackett SF, Sick A, Campochiaro PA: Reduction of p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina. J Cell Physiol. 2006 Dec;209(3):996-1005. Compared to eyes injected with GFP siRNA, those injected with p66Shc siRNA showed less loss of retinal function as assessed by electroretinograms from paraquat-induced oxidative stress. |
91(1,1,2,6) | Details |
| 15761239 | Holzenberger M: The role of insulin-like signalling in the regulation of ageing. Horm Res. 2004;62 Suppl 1:89-92. Resistance to oxidative stress in these mutant animals could be caused by decreased phosphorylation of molecules downstream of the IGF-I receptor in the IGF-I signalling pathway, one of which is thought to be p66shc. |
1(0,0,0,1) | Details |
| 10580504 | Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG: The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999 Nov 18;402(6759):309-13. We show that: (1) p66shc is serine phosphorylated upon treatment with peroxide (H2O2) or irradiation with ultraviolet light; (2) ablation of p66shc enhances cellular resistance to apoptosis induced by H2O2 or ultraviolet light; (3) a serine-phosphorylation defective mutant of p66shc cannot restore the normal stress response in p66shc-/- cells; (4) the p53 and p21 stress response is impaired in p66shc-/- cells; (5) p66shc-/- mice have increased resistance to paraquat and a 30% increase in life span. |
34(0,1,1,4) | Details |