Protein Information

Name smooth muscle actin
Synonyms ACTC; ACTC 1; ACTC1; Alpha cardiac actin; CMD1R; Smooth muscle actin; Alpha cardiac actins; Smooth muscle actins

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
19969051 Lang YD, Chang SF, Wang LF, Chen CM: Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett. 2010 Mar 1;193(1):19-25. Epub 2009 Dec 5.

Furthermore, paraquat enhanced Ang II and collagen type I mRNA and protein expression, alpha-smooth muscle actin, and chymase protein and chymase small interfering RNA inhibited these effects.
31(0,1,1,1) Details
18855938 Abrahan CE, Insua MF, Politi LE, German OL, Rotstein NP: Oxidative stress promotes proliferation and dedifferentiation of retina glial cells in vitro. J Neurosci Res. 2009 Mar;87(4):964-77.

Treatment of glial cell cultures prepared from rat retinas with the oxidant paraquat (PQ) did not induce glial cell apoptosis.
PQ decreased expression of a marker of differentiated glial cells, simultaneously increasing the expression of smooth muscle actin, shown to increase with glial dedifferentiation, the levels of cell-cycle markers, and the number of glial cells in the cultures.
1(0,0,0,1) Details