| Name | diaphorase |
|---|---|
| Synonyms | Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19526292 | Ortiz-Ortiz MA, Moran JM, Gonzalez-Polo RA, Niso-Santano M, Soler G, Bravo-San Pedro JM, Fuentes JM: -mediated toxicity in paraquat-exposed SH-SY5Y cells: a protective role of 7-nitroindazole. Neurotox Res. 2009 Aug;16(2):160-73. Epub 2009 May 30. The importance of the -diaphorase activity of NOSs in paraquat toxicity, in addition to the production of NO, has previously been reported as a mechanism of toxicity. |
31(0,1,1,1) | Details |
| 10910079 | Siemankowski LM, Morreale J, Butts BD, Briehl MM: Increased tumor necrosis factor-alpha sensitivity of MCF-7 cells transfected with NAD (P) H:quinone reductase. Cancer Res. 2000 Jul 1;60(13):3638-44. NAD (P) H:(quinone acceptor) oxidoreductase (NQO1) is an antioxidant enzyme with particular relevance to cancer. This increased sensitivity could not be explained by changes in superoxide dismutase or catalase activity or to increased sensitivity to oxidative stress in general, as assessed by response to peroxide and paraquat treatment. |
7(0,0,0,7) | Details |
| 15871734 | Sturve J, Stephensen E, Forlin L: Effects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss). Comp Hepatol. 2005 May 4;4(1):4. RESULTS: In rainbow trout, hepatic DTD activity is induced by the bifunctional AHR agonists beta-NF and B (a) P and the monofunctional inducers naphthazarin, and paraquat. |
2(0,0,0,2) | Details |
| 12387848 | Girardini JE, Dissous C, Serra E: Schistosoma mansoni ferredoxin (H) oxidoreductase and its role in detoxification. Mol Biochem Parasitol. 2002 Sep-Oct;124(1-2):37-45. Gel diaphorase activity and western blot assays demonstrated that SmFNR represented the major diaphorase activity of adult worms. |
1(0,0,0,1) | Details |
| 18062229 | Lee Y, Yeom J, Kang YS, Kim J, Sung JS, Jeon CO, Park W: Molecular characterization of fprB (ferredoxin- reductase) in Pseudomonas putida KT2440. J Microbiol Biotechnol. 2007 Sep;17(9):1504-12. The diaphorase activity assay was conducted using purified FprB to identify the function of FprB. In contrast to the fpr gene, the induction of fprB was not affected by oxidative stress agents, such as paraquat, H2O2 and t-butyl hydroperoxide. |
1(0,0,0,1) | Details |
| 17964427 | Kell A, Ventura N, Kahn N, Johnson TE: Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec 1;43(11):1560-6. Epub 2007 Sep 7. The SKN-1 transcription factor specifies cell fate of the EMS blastomere at the four-cell stage in the nematode Caenorhabditis elegans and also directs transcription of many genes responding to oxidative stress, including glutathione S-transferase, NAD (P) H:quinone oxidoreductase, and superoxide dismutase. SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric and azide. |
1(0,0,0,1) | Details |
| 11926994 | Yumino K, Kawakami I, Tamura M, Hayashi T, Nakamura M: Paraquat- and diquat-induced radical generation and lipid peroxidation in rat brain microsomes. J Biochem. 2002 Apr;131(4):565-70. |
0(0,0,0,0) | Details |
| 10535996 | Day BJ, Patel M, Calavetta L, Chang LY, Stamler JS: A mechanism of paraquat toxicity involving synthase. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12760-5. |
0(0,0,0,0) | Details |