Protein Information

Name transketolase
Synonyms TK; TKT; TKT 1; TKT1; Transketolase; Transketolase variant; Transketolases; Transketolase variants

Compound Information

Name paraquat
CAS 1,1′-dimethyl-4,4′-bipyridinium

Reference List

PubMed Abstract RScore(About this table)
11960673 de Roode DF, Vuorinen PJ, Bosveld AT: Effects of furazolidone, PCB77, PCB126, Aroclor 1248, paraquat and p,p'-DDE on transketolase activity in embryonal chicken brain. Toxicology. 2002 May 1;173(3):203-10.
16(0,0,2,6) Details
12453665 Akerman G, Amcoff P, Tjarnlund U, Fogelberg K, Torrissen O, Balk L: Paraquat and menadione exposure of rainbow trout (Oncorhynchus mykiss)--studies of effects on the pentose-phosphate shunt and thiamine levels in liver and kidney. Chem Biol Interact. 2003 Jan 6;142(3):269-83.

Depletion of NADPH increases metabolism through the pentose-phosphate shunt and may thereby increase the need for thiamine diphosphate by heightened transketolase activity.
2(0,0,0,2) Details
19129474 Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG: Cu, Zn superoxide dismutase and NADP (H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell. 2009 Mar;20(5):1493-508. Epub 2009 Jan 7.

Prior adaptation of the hac1 mutant deficient in the unfolded protein response (UPR) to the superoxide-generating agent paraquat reduced cell death under ER stress.
Sensitivity of the sod1 mutant to ER stress and decreased UPR induction was partially rescued by overexpression of TKL1 encoding transketolase.
1(0,0,0,1) Details