| Name | c Jun N terminal kinase 1 |
|---|---|
| Synonyms | Mitogen activated protein kinase 8; JNK 1; JNK 46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2… |
| Name | paraquat |
|---|---|
| CAS | 1,1′-dimethyl-4,4′-bipyridinium |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16687388 | Niso-Santano M, Moran JM, Garcia-Rubio L, Gomez-Martin A, Gonzalez-Polo RA, Soler G, Fuentes JM: Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. Toxicol Sci. 2006 Aug;92(2):507-15. Epub 2006 May 9. |
255(2,5,5,5) | Details |
| 19786089 | Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA: Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med. 2009 Dec 15;47(12):1753-61. Epub 2009 Sep 26. This study shows that phosphorylation of the stress-activated protein kinases ERK1/2 induced by peroxide, cadmium, or paraquat is attenuated in cells from these mice. |
31(0,1,1,1) | Details |
| 11181820 | Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH: Dopaminergic cell death induced by MPP (+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem. 2001 Feb;76(4):1010-21. Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP (+) (the active metabolite of MPTP), paraquat, dieldrin, and Our initial experiments revealed that treatment with both MPP (+) and the other PD-related neurotoxicants induced apoptotic cell death in SN4741 cells, following initial increases of H (2) O (2)-related ROS activity and subsequent activation of JNK1/2 MAP kinases. |
1(0,0,0,1) | Details |