Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9626535 Karan V, Vitorovic S, Tutundzic V, Poleksic V: Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. Ecotoxicol Environ Saf. 1998 May-Jun;40(1-2):49-55.

After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CuSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined.
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19685012 Arredondo M, Nunez H, Lopez G, Pizarro F, Ayala M, Araya M: Influence of Estrogens on Copper Indicators: In Vivo and In Vitro Studies. Biol Trace Elem Res. 2009 Aug 14.

Participants received 8 mg Cu/day (as copper sulfate) during 6 months.
Serum Cp and Cu, Cu-Zn-superoxide dismutase activity, liver function indicators [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyltransferase (GGT)], and serum Fe and Zn concentrations were measured monthly.
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1890621 Suntres ZE, Lui EM: Age-related differences in iron-nitrilotriacetate hepatotoxicity in the guinea pig: role of copper metallothionein. J Pharmacol Exp Ther. 1991 Sep;258(3):797-806.


Results of this study showed that the hepatotoxic response to FeNTA (3.5 mg Fe /kg i.p.) as measured by elevation in serum aspartate aminotransferase activity, increase in lipid peroxidation, decrease in reduced glutathione/oxidized glutathione ratio and histopathological changes was higher in 3-day-old than in 7-day-old and adult guinea pigs.
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12209195 Hebert C: NTP technical report on the toxicity studies of Cupric Sulfate (CAS No. 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3F1 Mice. Toxic Rep Ser. 1993 Jul;29:1-D3.

Increases in urinary glucose and N-acetyl-beta-D-glucosaminidase (a lysosomal enzyme) and aspartate aminotransferase (alpha-cytosolic enzyme) were suggestive of renal tubule epithelial damage.
Synonyms: Chalcanthite; Copper sulfate; cupric sulfate pentahydrate; bluestone; blue vitriol; Roman vitriol; Salzburg vitriol. (NOTE: These studies were supported in part by funds from the Comprehensive Environmental Response, Compensation, and Liability Act trust fund (Superfund) by an interagency agreement with the Agency for Toxic Substances and Disease Registry, U.S.
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20045542 Bampidis VA, Christodoulou V, Chatzipanagiotou A, Sossidou E, Salangoudis A: Serum enzyme status of Chios ewes fed increasing amounts of copper from copper sulfate. Res Vet Sci. 2009 Dec 31.

This study aimed to evaluate effects of orally administered copper (Cu) to Chios sheep breed on serum levels of aspartate aminotransferase (AST), l-alanine aminotransferase (ALT), lactate deydrogenase (LDH) and alkaline phosphatase (ALP), in order to establish a practical and effective method in diagnosing the prehemolytic stage of chronic Cu poisoning.
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11182525 Yamamoto H, Watanabe T, Mizuno H, Endo K, Hosokawa T, Kazusaka A, Gooneratne R, Fujita S: In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis. Free Radic Biol Med. 2001 Mar 1;30(5):547-54.


D-mannitol treatment suppressed the increases in serum aspartate aminotransferase activity and total bilirubin concentration.
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