Protein Information

Name protein kinase C (protein family or complex)
Synonyms Protein kinase C; PKC

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
10547182 Wood JL, Graham A: Reduction of transition metals by human (THP-1) monocytes is enhanced by activators of protein kinase C. Free Radic Res. 1999 Nov;31(5):367-79.

3(0,0,0,3) Details
8512313 Taher MM, Garcia JG, Natarajan V: Hydroperoxide-induced diacylglycerol formation and protein kinase C activation in vascular endothelial cells. Arch Biochem Biophys. 1993 Jun;303(2):260-6.

2(0,0,0,2) Details
8111635 Krivanek J: Protein kinase C in nucleus parabrachialis: effect of drugs inducing conditioned taste aversion. Brain Res. 1993 Dec 3;629(2):327-30.

2(0,0,0,2) Details
1554379 Pelletier O, Hill I, Birnboim HC: Inhibition by superoxide dismutase-mimetic copper complexes of phorbol ester-induced respiratory burst in human granulocytes. Biochem Pharmacol. 1992 Mar 3;43(5):1061-6.

Similar inhibitory effects were seen using copper sulfate.
It appears that these lipophilic SOD-mimetic compounds can, in the presence of H2O2 and O2-, give rise to a species that can inhibit some component of the respiratory burst oxidase or protein kinase C in intact granulocytes and xanthine oxidase in solution.
1(0,0,0,1) Details
8524237 Wang HD, Yuh CH, Dang CV, Johnson DL: The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol Cell Biol. 1995 Dec;15(12):6720-8.


By using various kinase inhibitors, it was found that the X-mediated increases in both transcription and TBP are dependent upon protein kinase C activation.
1(0,0,0,1) Details