Protein Information

Name vascular endothelial growth factor
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
19182977 Barralet J, Gbureck U, Habibovic P, Vorndran E, Gerard C, Doillon CJ: Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release. Tissue Eng Part A. 2009 Jul;15(7):1601-9.

The purpose of this study was to compare tissue responses to 3D printed macroporous bioceramic scaffolds implanted in mice that had been loaded with either VEGF or copper sulfate.
13(0,0,2,3) Details
11959648 Sen CK, Khanna S, Venojarvi M, Trikha P, Ellison EC, Hunt TK, Roy S: Copper-induced vascular endothelial growth factor expression and wound healing. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1821-7.

At physiologically relevant concentrations, copper sulfate induced VEGF expression in primary as well as transformed human keratinocytes.
10(0,0,1,5) Details
17327471 Zhou Y, Jiang Y, Kang YJ: Copper inhibition of hydrogen peroxide-induced hypertrophy in embryonic rat cardiac H9c2 cells. Exp Biol Med. 2007 Mar;232(3):385-9.


Previous studies have shown that dietary copper deficiency causes cardiac hypertrophy and depression of vascular epithelial growth factor (VEGF) expression in mouse model.
5(0,0,0,5) Details
18495151 Zhou Y, Jiang Y, Kang YJ: Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size. J Mol Cell Cardiol. 2008 Jul;45(1):106-17. Epub 2008 Apr 9.

The hypertrophied cardiomyocytes were exposed to copper sulfate at a final concentration of 5 microM in cultures for additional 24 h.
4(0,0,0,4) Details
19542178 Zhou Y, Bourcy K, Kang YJ: Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Cardiovasc Res. 2009 Oct 1;84(1):54-63. Epub 2009 Jun 19.

AIMS: Vascular endothelial growth factor (VEGF) has been well documented to stimulate cell proliferation and differentiation; however, we have observed that copper (Cu)-induced regression of heart hypertrophy was VEGF-dependent.
The hypertrophic cardiomyocytes were exposed to copper sulfate at a final concentration of 5 microM in cultures for 24 h with a concomitant presence of PE.
3(0,0,0,3) Details