Protein Information

Name HXK1
Synonyms Brain form hexokinase; HK1; Glycolytic enzyme; HK I; HK1 sa; HK1 sb; HK1 ta; HK1 tb…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
17031512 Ramon M, Rolland F, Thevelein JM, Van Dijck P, Leyman B: ABI4 mediates the effects of exogenous trehalose on Arabidopsis growth and starch breakdown. Plant Mol Biol. 2007 Jan;63(2):195-206. Epub 2006 Sep 23.

Here we show that the ABI4 transcription factor mediates the effects of trehalose on starch metabolism and growth, independently of abscisic acid (ABA) synthesis and hexokinase (HXK1) signaling.
81(1,1,1,1) Details
17720689 Aki T, Konishi M, Kikuchi T, Fujimori T, Yoneyama T, Yanagisawa S: Distinct modulations of the hexokinase1-mediated glucose response and hexokinase1-independent processes by HYS1/CPR5 in Arabidopsis. J Exp Bot. 2007;58(12):3239-48. Epub 2007 Aug 23.

Neither the glucose content nor the sensitivities to ethylene, cytokinin, and abscisic acid were found to differ between wild-type and hys1 seedlings.
However, disruption of the gene encoding hexokinase1 (HXK1), which acts as a glucose sensor, partially suppressed the glucose hypersensitive phenotype of the hys1 mutant.
3(0,0,0,3) Details
15516499 Avonce N, Leyman B, Mascorro-Gallardo JO, Van Dijck P, Thevelein JM, Iturriaga G: The Arabidopsis trehalose-6-P synthase AtTPS1 gene is a regulator of glucose, abscisic acid, and stress signaling. Plant Physiol. 2004 Nov;136(3):3649-59. Epub 2004 Oct 29.

In the presence of Glc, CAB1 expression remained high, whereas ABI4, HXK1, and ApL3 levels were down-regulated in the AtTPS1-overexpressing lines.
2(0,0,0,2) Details
18410483 Teng S, Rognoni S, Bentsink L, Smeekens S: The Arabidopsis GSQ5/DOG1 Cvi allele is induced by the ABA-mediated sugar signalling pathway, and enhances sugar sensitivity by stimulating ABI4 expression. Plant J. 2008 Aug;55(3):372-81. Epub 2008 Apr 12.


ABI4 activity is induced via the ABA-mediated sugar signalling pathway, which is initiated by the glucose sensing protein hexokinase.
1(0,0,0,1) Details
15611148 Thelander M, Olsson T, Ronne H: Effect of the energy supply on filamentous growth and development in Physcomitrella patens. J Exp Bot. 2005 Feb;56(412):653-62. Epub 2004 Dec 20.

These experiments were performed both in a wild-type strain and in a hxk1 knockout mutant which lacks the major hexokinase of Physcomitrella.
The hxk1 mutation also causes buds to appear on chloronemal filaments, which is rarely seen in the wild type, and shows increased sensitivity to cytokinin and abscisic acid.
1(0,0,0,1) Details
18599644 Quettier AL, Shaw E, Eastmond PJ: SUGAR-DEPENDENT6 encodes a mitochondrial flavin adenine dinucleotide-dependent glycerol-3-p dehydrogenase, which is required for glycerol catabolism and post germinative seedling growth in Arabidopsis. Plant Physiol. 2008 Sep;148(1):519-28. Epub 2008 Jul 3.


The activity of the glycolytic enzyme phosphoglucose isomerase is competitively inhibited by G3P in vitro.
1(0,0,0,1) Details
15284498 Yang Z, Zhang L, Diao F, Huang M, Wu N: Sucrose regulates elongation of carrot somatic embryo radicles as a signal molecule. Plant Mol Biol. 2004 Feb;54(3):441-59.


It is thus inferred that this sucrose-signaling pathway may be independent of hexokinase.
1(0,0,0,1) Details
19513234 Baguma Y, Sun C, Boren M, Olsson H, Rosenqvist S, Mutisya J, Rubaihayo PR, Jansson C: Sugar-mediated semidian oscillation of gene expression in the cassava storage root regulates starch synthesis. Plant Signal Behav. 2008 Jul;3(7):439-45.


Abscisic acid (ABA) was another potent inducer of SBE expression.
0(0,0,0,0) Details
18573192 Zhang H, Xie X, Kim MS, Kornyeyev DA, Holaday S, Pare PW: Soil bacteria augment Arabidopsis photosynthesis by decreasing glucose sensing and abscisic acid levels in planta. Plant J. 2008 Oct;56(2):264-73. Epub 2008 Jun 28.

0(0,0,0,0) Details