Protein Information

Name RAB18
Synonyms RAB18; RAB18 small GTPase; RAB18LI1; Ras associated protein RAB18; Ras related GTP binding protein 18; Ras related protein Rab 18; RAB18 small GTPases; Ras associated protein RAB18s…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
15807778 Zalejski C, Zhang Z, Quettier AL, Maldiney R, Bonnet M, Brault M, Demandre C, Miginiac E, Rona JP, Sotta B, Jeannette E: Diacylglycerol pyrophosphate is a second messenger of abscisic acid signaling in Arabidopsis thaliana suspension cells. Plant J. 2005 Apr;42(2):145-52.

In a previous study, we demonstrated that the stimulation of phospholipase D (PLD) activity and plasma membrane anion currents by ABA were both required for RAB18 expression in Arabidopsis thaliana suspension cells.
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18768909 Ghelis T, Bolbach G, Clodic G, Habricot Y, Miginiac E, Sotta B, Jeannette E: Protein tyrosine kinases and protein tyrosine phosphatases are involved in abscisic acid-dependent processes in Arabidopsis seeds and suspension cells. Plant Physiol. 2008 Nov;148(3):1668-80. Epub 2008 Sep 3.

Phenylarsine oxide, a specific inhibitor of protein Tyr phosphatase activity, abolished the ABA-dependent accumulation of RAB18 (responsive to ABA 18) transcripts.
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19033529 Saez A, Rodrigues A, Santiago J, Rubio S, Rodriguez PL: HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis. Plant Cell. 2008 Nov;20(11):2972-88. Epub 2008 Nov 25.

Bimolecular fluorescence complementation and coimmunoprecipitation assays confirmed the interaction of HAB1 and SWI3B in the nucleus of plant cells. swi3b mutants showed a reduced sensitivity to ABA-mediated inhibition of seed germination and growth and reduced expression of the ABA-responsive genes RAB18 and RD29B.
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16889651 Quettier AL, Bertrand C, Habricot Y, Miginiac E, Agnes C, Jeannette E, Maldiney R: The phs1-3 mutation in a putative dual-specificity protein tyrosine phosphatase gene provokes hypersensitive responses to abscisic acid in Arabidopsis thaliana. Plant J. 2006 Sep;47(5):711-9. Epub 2006 Aug 2.

The upregulation of two ABA-induced genes (At5g06760, RAB18) and the downregulation of two ABA-repressed genes (AtCLC-A, ACL) are enhanced in the phs1-3 mutant compared with the wild-type.
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19210750 Park MY, Chung MS, Koh HS, Lee DJ, Ahn SJ, Kim CS: Isolation and functional characterization of the Arabidopsis salt-tolerance 32 (AtSAT32) gene associated with salt tolerance and ABA signaling. Physiol Plant. 2009 Apr;135(4):426-35. Epub 2009 Feb 5.


Consistent with these observations, 35S::AtSAT32 plants exhibited increased expression of salt-responsive and ABA-responsive genes, including the Rd29A, Erd15, Rd29B, Rd22 and RAB18 genes.
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17001447 Cao S, Jiang L, Song S, Jing R, Xu G: AtGRP7 is involved in the regulation of abscisic acid and stress responses in Arabidopsis. Cell Mol Biol Lett. 2006;11(4):526-35. Epub 2006 Sep 26.

In addition, the atgrp7-1 mutant plants accumulated significantly higher transcript levels of two ABA-and stress-inducible genes, RD29A and RAB18, compared with the wild-type plants.
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18470484 Wang Q, Guan Y, Wu Y, Chen H, Chen F, Chu C: Overexpression of a rice OsDREB1F gene increases salt, drought, and low temperature tolerance in both Arabidopsis and rice. Plant Mol Biol. 2008 Aug;67(6):589-602. Epub 2008 May 10.


The further characterisation of OsDREB1F-overexpressing Arabidopsis showed that, besides activating the expression of COR genes which contain DRE/CRT element in their upstream promoter regions, the expression of rd29B and RAB18 genes were also activated, suggested that OsDREB1F may also participate in ABA-dependent pathway.
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19895399 Li S, Xu C, Yang Y, Xia G: Functional analysis of TaDi19A, a salt-responsive gene in wheat. Plant Cell Environ. 2010 Jan;33(1):117-29. Epub 2009 Nov 4.

TaDi19A was constitutively expressed in both the root and leaf of wheat seedlings grown under non-stressed conditions, but was substantially up-regulated by the imposition of stress (salinity, osmotic stress and cold), or the supply of stress-related hormones [abscisic acid (ABA) and ethylene].
The expression of the ABA signal pathway genes ABI1, RAB18, ERD15 and ABF3, and SOS2 (SOS pathway) was altered in the transgenic lines.
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16815952 Reyes D, Rodriguez D, Gonzalez-Garcia MP, Lorenzo O, Nicolas G, Garcia-Martinez JL, Nicolas C: Overexpression of a protein phosphatase 2C from beech seeds in Arabidopsis shows phenotypes related to abscisic acid responses and gibberellin biosynthesis. Plant Physiol. 2006 Aug;141(4):1414-24. Epub 2006 Jun 30.

Additionally, FsPP2C2-overexpressing plants showed a strong induction of the Responsive to ABA 18 (RAB18) gene.
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19584117 Guo J, Wang J, Xi L, Huang WD, Liang J, Chen JG: RACK1 is a negative regulator of ABA responses in Arabidopsis. J Exp Bot. 2009;60(13):3819-33. Epub 2009 Jul 7.


It was found that the ABA-responsive marker genes, RD29B and RAB18, were up-regulated in rack1a mutants.
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16024687 Tanaka Y, Sano T, Tamaoki M, Nakajima N, Kondo N, Hasezawa S: Ethylene inhibits abscisic acid-induced stomatal closure in Arabidopsis. Plant Physiol. 2005 Aug;138(4):2337-43. Epub 2005 Jul 15.

Moreover, expression of the ABA-induced gene RAB18 was reduced following ACC application.
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15564532 Nishimura N, Yoshida T, Murayama M, Asami T, Shinozaki K, Hirayama T: Isolation and characterization of novel mutants affecting the abscisic acid sensitivity of Arabidopsis germination and seedling growth. Plant Cell Physiol. 2004 Oct;45(10):1485-99.

RT-PCR experiments showed that the expression patterns of the ABA-inducible genes RAB18, AtEm1, AtEm6 and ABI5 in germinating seeds were affected by these four ahg mutations, whereas those of ABI3 and ABI4 were not. ahg4 displayed slightly increased mRNA levels of several ABA-inducible genes upon ABA treatment.
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16766676 Zalejski C, Paradis S, Maldiney R, Habricot Y, Miginiac E, Rona JP, Jeannette E: Induction of abscisic acid-regulated gene expression by diacylglycerol pyrophosphate involves Ca2+ and anion currents in Arabidopsis suspension cells. Plant Physiol. 2006 Aug;141(4):1555-62. Epub 2006 Jun 9.

At5g06760, LTI30, RD29A, and RAB18 were stimulated by ABA and also specifically expressed in DGPP-treated cells.
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16211388 Reyes D, Rodriguez D, Nicolas G, Nicolas C: Evidence of a role for tyrosine dephosphorylation in the control of postgermination arrest of development by abscisic acid in Arabidopsis thaliana L. Planta. 2006 Jan;223(2):381-5. Epub 2005 Oct 7.

Consistent with this finding, we demonstrate that the ABA-responsive gene, RAB18, is hyperinduced in seeds imbibed in ABA plus PAO, compared with seeds imbibed only with ABA.
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19276109 Miura K, Lee J, Jin JB, Yoo CY, Miura T, Hasegawa PM: Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5418-23. Epub 2009 Mar 10.

Furthermore, expression of genes that are ABA-responsive through ABI5-dependent signaling (e.g., RD29A, Rd29B, AtEm6, RAB18, ADH1) was hyperinduced by the hormone in siz1 seedlings. abi5-4 suppressed ABA hypersensitivity caused by siz1 (siz1-2 abi5-4), demonstrating an epistatic genetic interaction between SIZ1 and ABI5.
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15053765 Ton J, Mauch-Mani B: Beta-amino-butyric acid-induced resistance against necrotrophic pathogens is based on ABA-dependent priming for callose. Plant J. 2004 Apr;38(1):119-30.


The expression of BABA-induced resistance against P. cucumerina was unaffected in mutants impaired in ethylene (ET) and SA signalling, but was blocked in the abscisic acid (ABA)-deficient mutant aba1-5, the ABA-insensitive mutant abi4-1 and the callose-deficient mutant pmr4-1.
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