Protein Information

Name ABI1
Synonyms ABI 1; ABI1; ABI1/MLL fusion gene; ABL interactor 1; Abelson interactor 1; Abi 1; Abl binding protein 4; Abl interactor protein 1 long…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
16798945 Saez A, Robert N, Maktabi MH, Schroeder JI, Serrano R, Rodriguez PL: Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Plant Physiol. 2006 Aug;141(4):1389-99. Epub 2006 Jun 23.
82(1,1,1,2) Details
19847119 Sakata Y, Komatsu K, Taji T, Tanaka S: Role of PP2C-mediated ABA signaling in the moss Physcomitrella patens. Plant Signal Behav. 2009 Sep;4(9):887-9. Epub 2009 Sep 7.

We have shown that the basal land plant Physcomitrella patens and the model plant Arabidopsis thaliana share a conserved abscisic acid (ABA) signaling pathway mediated through ABI1-related type 2C protein phosphatases (PP2Cs).
81(1,1,1,1) Details
16365038 Yoshida R, Umezawa T, Mizoguchi T, Takahashi S, Takahashi F, Shinozaki K: The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem. 2006 Feb 24;281(8):5310-8. Epub 2005 Dec 19.
39(0,1,2,4) Details
19880399 Fujita Y, Nakashima K, Yoshida T, Katagiri T, Kidokoro S, Kanamori N, Umezawa T, Fujita M, Maruyama K, Ishiyama K, Kobayashi M, Nakasone S, Yamada K, Ito T, Shinozaki K, Yamaguchi-Shinozaki K: Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Plant Cell Physiol. 2009 Dec;50(12):2123-32. Epub .

Further, our data show that these group-A PP2Cs, such as HAI1 and ABI1, interact with SRK2D.
1(0,0,0,1) Details
17427804 Kaliff M, Staal J, Myrenas M, Dixelius C: ABA is required for Leptosphaeria maculans resistance via ABI1- and ABI4-dependent signaling. Mol Plant Microbe Interact. 2007 Apr;20(4):335-45.

Abscisic acid (ABA) is a defense hormone with influence on callose-dependent and -independent resistance against Leptosphaeria maculans acting in the RLMcol pathway.
1(0,0,0,1) Details
17158582 Benschop JJ, Millenaar FF, Smeets ME, van Zanten M, Voesenek LA, Peeters AJ: Abscisic acid antagonizes ethylene-induced hyponastic growth in Arabidopsis. Plant Physiol. 2007 Feb;143(2):1013-23. Epub 2006 Dec 8.

Mutations in ABI1 or ABI3 induced a strong ethylene-regulated hyponastic growth in the less responsive accession Ler, while the response was abolished in the ABA-hypersensitive era1 in Col-0.
1(0,0,0,1) Details
18930563 Liu L, Hu X, Song J, Zong X, Li D, Li D: Over-expression of a Zea mays L. protein phosphatase 2C gene (ZmPP2C) in Arabidopsis thaliana decreases tolerance to salt and drought. J Plant Physiol. 2009 Mar 15;166(5):531-42. Epub 2008 Oct 18.


Under these stress conditions, they also showed decreased transcription of the stress-related genes RD29A, RD29B, P5CS1, and P5CS2, and ABA-related genes ABI1 and ABI2.
1(0,0,0,1) Details
19638448 Rodriguez MV, Mendiondo GM, Maskin L, Gudesblat GE, Iusem ND, Benech-Arnold RL: Expression of ABA signalling genes and ABI5 protein levels in imbibed Sorghum bicolor caryopses with contrasting dormancy and at different developmental stages. Ann Bot. 2009 Oct;104(5):975-85. Epub 2009 Jul 28.


METHODS: Sorghum genes encoding homologues for ABA signalling components from other species (ABI5, ABI4, VP1, ABI1 and PKABA1) were studied at the transcriptional and protein level (ABI5) during grain imbibition for two sorghum lines with contrasting sprouting phenotypes and in response to hormones.
1(0,0,0,1) Details
18088307 Flors V, Ton J, van Doorn R, Jakab G, Garcia-Agustin P, Mauch-Mani B: Interplay between JA, SA and ABA signalling during basal and induced resistance against Pseudomonas syringae and Alternaria brassicicola. Plant J. 2008 Apr;54(1):81-92. Epub 2007 Dec 15.


Pre-treatment with BABA antagonized this ABA accumulation, and concurrently potentiated expression of the ABA-responsive ABI1 gene.
1(0,0,0,1) Details
19855047 Vlad F, Rubio S, Rodrigues A, Sirichandra C, Belin C, Robert N, Leung J, Rodriguez PL, Lauriere C, Merlot S: Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis. Plant Cell. 2009 Oct;21(10):3170-84. Epub 2009 Oct 23.

Furthermore, HAB1 and the related PP2Cs ABI1 and ABI2 interact with OST1 in vivo, and mutations in the corresponding genes strongly affect OST1 activation by ABA.
1(0,0,0,1) Details
18162593 Jung C, Seo JS, Han SW, Koo YJ, Kim CH, Song SI, Nahm BH, Choi YD, Cheong JJ: Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis. Plant Physiol. 2008 Feb;146(2):623-35. Epub 2007 Dec 27.

Treatment with abscisic acid (ABA) induced AtMYB44 transcript accumulation within 30 min.
Microarray analysis and northern blots revealed that salt-induced activation of the genes that encode a group of serine/threonine protein phosphatases 2C (PP2Cs), such as ABI1, ABI2, AtPP2CA, HAB1, and HAB2, was diminished in transgenic plants overexpressing AtMYB44.
1(0,0,0,1) Details
19240210 Zhang S, Cai Z, Wang X: The primary signaling outputs of brassinosteroids are regulated by abscisic acid signaling. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4543-8. Epub 2009 Feb 24.

Also, using a set of ABA insensitive mutants, we found that regulation of ABA on the BR primary signaling pathway depends on the ABA early signaling components, ABI1 and ABI2.
1(0,0,0,1) Details
15504732 Zou X, Seemann JR, Neuman D, Shen QJ: A WRKY gene from creosote bush encodes an activator of the abscisic acid signaling pathway. J Biol Chem. 2004 Dec 31;279(53):55770-9. Epub 2004 Oct 25.

0(0,0,0,0) Details
16339800 Yoshida T, Nishimura N, Kitahata N, Kuromori T, Ito T, Asami T, Shinozaki K, Hirayama T: ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Plant Physiol. 2006 Jan;140(1):115-26. Epub 2005 Dec 9.

0(0,0,0,0) Details
20164209 Mosher S, Moeder W, Nishimura N, Jikumaru Y, Joo SH, Urquhart W, Klessig DF, Kim SK, Nambara E, Yoshioka K: The lesion mimic mutant cpr22 shows alterations in abscisic acid signaling and abscisic acid insensitivity in a salicylic acid-dependent manner. Plant Physiol. 2010 Feb 17.

0(0,0,0,0) Details
15197253 Zhang W, Qin C, Zhao J, Wang X: Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9508-13. Epub 2004 Jun 14.
35(0,1,1,5) Details
17261695 Mane SP, Vasquez-Robinet C, Sioson AA, Heath LS, Grene R: Early PLDalpha-mediated events in response to progressive drought stress in Arabidopsis: a transcriptome analysis. J Exp Bot. 2007;58(2):241-52.

PLDalpha1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and promotes abscisic acid signalling.
31(0,1,1,1) Details
18094993 Ribot C, Wang Y, Poirier Y: Expression analyses of three members of the AtPHO1 family reveal differential interactions between signaling pathways involved in phosphate deficiency and the responses to auxin, cytokinin, and abscisic acid. Planta. 2008 Apr;227(5):1025-36. Epub 2007 Dec 19.

The inhibition of expression by abscisic acid of AtPHO1 and AtPHO1;H1, and of the Pi-starvation responsive genes AtPHT1;1 and AtIPS1, was dependant on the ABI1 type 2C protein phosphatase.
31(0,1,1,1) Details
19690149 Zhang Y, Zhu H, Zhang Q, Li M, Yan M, Wang R, Wang L, Welti R, Zhang W, Wang X: Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell. 2009 Aug;21(8):2357-77. Epub 2009 Aug 18.


We determined the role of Phospholipase Dalpha1 (PLDalpha1) and its lipid product phosphatidic acid (PA) in abscisic acid (ABA)-induced production of reactive oxygen species (ROS) in Arabidopsis thaliana guard cells.
0(0,0,0,0) Details
19266168 Komatsu K, Nishikawa Y, Ohtsuka T, Taji T, Quatrano RS, Tanaka S, Sakata Y: Functional analyses of the ABI1-related protein phosphatase type 2C reveal evolutionarily conserved regulation of abscisic acid signaling between Arabidopsis and the moss Physcomitrella patens. Plant Mol Biol. 2009 Jun;70(3):327-40. Epub 2009 Mar 6.
7(0,0,1,2) Details
20097789 Tougane K, Komatsu K, Bhyan SB, Sakata Y, Ishizaki K, Yamato KT, Kohchi T, Takezawa D: Evolutionarily conserved regulatory mechanisms of abscisic acid signaling in land plants: characterization of ABSCISIC ACID INSENSITIVE1-like type 2C protein phosphatase in the liverwort Marchantia polymorpha. Plant Physiol. 2010 Mar;152(3):1529-43. Epub 2010 Jan 22.

In this study, we isolated and characterized MpABI1, an ortholog of ABSCISIC ACID INSENSITIVE1 (ABI1), from the liverwort Marchantia polymorpha.
6(0,0,1,1) Details
19513806 Cheng WH, Chiang MH, Hwang SG, Lin PC: Antagonism between abscisic acid and ethylene in Arabidopsis acts in parallel with the reciprocal regulation of their metabolism and signaling pathways. Plant Mol Biol. 2009 Sep;71(1-2):61-80. Epub 2009 Jun 10.

Moreover, by microarray analysis we found that an ACC oxidase (ACO) was significantly upregulated in the aba2 mutant, whereas the 9-CIS-EPOXYCAROTENOID DIOXYGENASE 3 (NCED3) gene in ein2 was upregulated, and both the ABSCISIC ACID INSENSITIVE1 (ABI1) and cytochrome P450, family 707, subfamily A, polypeptide 2 (CYP707A2) genes in etr1-1 were downregulated.
6(0,0,1,1) Details
19837818 Arend M, Schnitzler JP, Ehlting B, Hansch R, Lange T, Rennenberg H, Himmelbach A, Grill E, Fromm J: Expression of the Arabidopsis mutant ABI1 gene alters abscisic acid sensitivity, stomatal development, and growth morphology in gray poplars. Plant Physiol. 2009 Dec;151(4):2110-9. Epub 2009 Oct 16.
7(0,0,1,2) Details
15356325 Baier M, Stroher E, Dietz KJ: The acceptor availability at photosystem I and ABA control nuclear expression of 2-Cys peroxiredoxin-A in Arabidopsis thaliana. Plant Cell Physiol. 2004 Aug;45(8):997-1006.

Analysis of 2CPA promoter regulation in the abscisic acid (ABA)-biosynthetic mutants aba2 and aba3 and the ABA-insensitive mutants abi1 and abi2 support a regulatory circuitry in which the redox signal cross-talks with the ABA-signaling cascade downstream of ABI1 and ABI2.
6(0,0,1,1) Details
19874541 Nishimura N, Sarkeshik A, Nito K, Park SY, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI: PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010 Jan;61(2):290-9. Epub 2009 Oct 26.

Abscisic acid (ABA) mediates resistance to abiotic stress and controls developmental processes in plants.
6(0,0,0,6) Details
19705149 Ludwikow A, Kierzek D, Gallois P, Zeef L, Sadowski J: Gene expression profiling of ozone-treated Arabidopsis abi1td insertional mutant: protein phosphatase 2C ABI1 modulates biosynthesis ratio of ABA and ethylene. Planta. 2009 Oct;230(5):1003-17. Epub 2009 Aug 25.

We report on the characterization of the interaction between reactive oxygen species signalling and abscisic acid (ABA)-mediated gene network in ozone (O (3)) stress response.
6(0,0,0,6) Details
18298671 Moes D, Himmelbach A, Korte A, Haberer G, Grill E: Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis. Plant J. 2008 Jun;54(5):806-19. Epub 2008 Feb 22.


ABI1, a protein phosphatase 2C, is a key component of ABA signal transduction in Arabidopsis that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.
6(0,0,0,6) Details
15604708 Olsson AS, Engstrom P, Soderman E: The homeobox genes ATHB12 and ATHB7 encode potential regulators of growth in response to water deficit in Arabidopsis. Plant Mol Biol. 2004 Jul;55(5):663-77.

ATHB12 ,like ATHB7 ,was up-regulated during water deficit conditions, the up-regulation being dependent on abscisic acid (ABA) and on the activity of the Ser/Thr phosphatases ABI1 and ABI2.
6(0,0,1,1) Details
17304219 de Torres-Zabala M, Truman W, Bennett MH, Lafforgue G, Mansfield JW, Rodriguez Egea P, Bogre L, Grant M: Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease. EMBO J. 2007 Mar 7;26(5):1434-43. Epub 2007 Feb 15.

Strongly induced were NCED3, encoding a key enzyme of ABA biosynthesis, and the abscisic acid insensitive 1 (ABI1) clade of genes encoding protein phosphatases type 2C (PP2Cs) involved in the regulation of ABA signalling.
6(0,0,1,1) Details
19893533 Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N: Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5.

Upon binding to ABA, a PYL protein associates with type 2C protein phosphatases (PP2Cs) such as ABI1 and ABI2, inhibiting their activity; the molecular mechanisms by which PYLs mediate ABA signaling remain unknown, however.
4(0,0,0,4) Details
19855379 Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M: Structural basis of abscisic acid signalling. Nature. 2009 Dec 3;462(7273):609-14.

Here we present the crystal structures of the ABA receptor PYL1 bound with (+)-ABA, and the complex formed by the further binding of (+)-ABA-bound PYL1 with the PP2C protein ABI1.
3(0,0,0,3) Details
19407143 Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, Grill E: Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009 May 22;324(5930):1064-8. Epub 2009 Apr 30.

Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses.
4(0,0,0,4) Details
19769575 Szostkiewicz I, Richter K, Kepka M, Demmel S, Ma Y, Korte A, Assaad FF, Christmann A, Grill E: Closely related receptor complexes differ in their ABA selectivity and sensitivity. Plant J. 2010 Jan;61(1):25-35. Epub 2009 Sep 21.

In the case of the hormone abscisic acid (ABA), which regulates plant responses to abiotic stress, perception seems to occur both at the plasma membrane and in the cytosol.
RCAR3 was identified in a screen for interactors of the PP2Cs ABI1 and ABI2, which are key regulators of ABA responses.
3(0,0,0,3) Details
16571665 Yang Y, Sulpice R, Himmelbach A, Meinhard M, Christmann A, Grill E: Fibrillin expression is regulated by abscisic acid response regulators and is involved in abscisic acid-mediated photoprotection. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6061-6. Epub 2006 Mar 29.

ABA induces fibrillin accumulation, and the ABA response regulators ABI1 and ABI2 regulate fibrillin expression.
2(0,0,0,2) Details
16805735 Marella HH, Sakata Y, Quatrano RS: Characterization and functional analysis of ABSCISIC ACID INSENSITIVE3-like genes from Physcomitrella patens. Plant J. 2006 Jun;46(6):1032-44.

We also show the involvement of ABI1 in the pathway, utilizing the abi1-1 mutant allele.
1(0,0,0,1) Details
19624469 Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Marquez JA, Cutler SR, Rodriguez PL: Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs. Plant J. 2009 Nov;60(4):575-88. Epub 2009 Jul 16.

PYL5 and other members of its protein family inhibited HAB1, ABI1 and ABI2 phosphatase activity in an ABA-dependent manner.
1(0,0,0,1) Details
19955405 Geiger D, Scherzer S, Mumm P, Stange A, Marten I, Bauer H, Ache P, Matschi S, Liese A, Al-Rasheid KA, Romeis T, Hedrich R: Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21425-30. Epub 2009 Dec 2.

In response to drought stress the phytohormone ABA (abscisic acid) induces stomatal closure and, therein, activates guard cell anion channels in a calcium-dependent as well as-independent manner.
Two key components of the ABA signaling pathway are the protein kinase OST1 (open stomata 1) and the protein phosphatase ABI1 (ABA insensitive 1).
3(0,0,0,3) Details
16614222 Mishra G, Zhang W, Deng F, Zhao J, Wang X: A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science. 2006 Apr 14;312(5771):264-6.

PLDalpha1-produced phosphatidic acid (PA) binds to the ABI1 PP2C to signal ABA-promoted stomatal closure, whereas PLDalpha1 and PA interact with the Galpha subunit of heterotrimeric G protein to mediate ABA inhibition of stomatal opening.
1(0,0,0,1) Details
19458118 Rubio S, Rodrigues A, Saez A, Dizon MB, Galle A, Kim TH, Santiago J, Flexas J, Schroeder JI, Rodriguez PL: Triple loss of function of protein phosphatases type 2C leads to partial constitutive response to endogenous abscisic acid. Plant Physiol. 2009 Jul;150(3):1345-55. Epub 2009 May 20.

Specifically, HAB1, ABI1, ABI2, and PP2CA have been shown to affect both seed and vegetative responses to ABA.
1(0,0,0,1) Details
19895399 Li S, Xu C, Yang Y, Xia G: Functional analysis of TaDi19A, a salt-responsive gene in wheat. Plant Cell Environ. 2010 Jan;33(1):117-29. Epub 2009 Nov 4.

TaDi19A was constitutively expressed in both the root and leaf of wheat seedlings grown under non-stressed conditions, but was substantially up-regulated by the imposition of stress (salinity, osmotic stress and cold), or the supply of stress-related hormones [abscisic acid (ABA) and ethylene].
The expression of the ABA signal pathway genes ABI1, RAB18, ERD15 and ABF3, and SOS2 (SOS pathway) was altered in the transgenic lines.
1(0,0,0,1) Details
18365246 Liao Y, Zou HF, Wei W, Hao YJ, Tian AG, Huang J, Liu YF, Zhang JS, Chen SY: Soybean GmbZIP44, GmbZIP62 and GmbZIP78 genes function as negative regulator of ABA signaling and confer salt and freezing tolerance in transgenic Arabidopsis. Planta. 2008 Jul;228(2):225-40. Epub 2008 Mar 26.


The GmbZIP44, GmbZIP62 and GmbZIP78 may function in ABA signaling through upregulation of ABI1 and ABI2 and play roles in stress tolerance through regulation of various stress-responsive genes.
1(0,0,0,1) Details
19924127 Fujii H, Chinnusamy V, Rodrigues A, Rubio S, Antoni R, Park SY, Cutler SR, Sheen J, Rodriguez PL, Zhu JK: In vitro reconstitution of an abscisic acid signalling pathway. Nature. 2009 Dec 3;462(7273):660-4. Epub 2009 Nov 18.

Here we show that by combining the recently identified ABA receptor PYR1 with the type 2C protein phosphatase (PP2C) ABI1, the serine/threonine protein kinase SnRK2.6/OST1 and the transcription factor ABF2/AREB1, we can reconstitute ABA-triggered phosphorylation of the transcription factor in vitro.
1(0,0,0,1) Details
17092320 Mowla SB, Cuypers A, Driscoll SP, Kiddle G, Thomson J, Foyer CH, Theodoulou FL: Yeast complementation reveals a role for an Arabidopsis thaliana late embryogenesis abundant (LEA)-like protein in oxidative stress tolerance. Plant J. 2006 Dec;48(5):743-56. Epub 2006 Nov 8.

Use of abi1-1 (ABA-insensitive) and aba1-1 (ABA-deficient) Arabidopsis mutants indicated that drought induction of AtLEA5 required ABA synthesis but was independent of the ABI1 gene product.
Abscisic acid and H (2) O (2) induction of AtLEA5 was also independent of the OXI1 protein kinase.
1(0,0,0,1) Details
15599761 Dong HP, Yu H, Bao Z, Guo X, Peng J, Yao Z, Chen G, Qu S, Dong H: The ABI2-dependent abscisic acid signalling controls HrpN-induced drought tolerance in Arabidopsis. Planta. 2005 Jun;221(3):313-27. Epub 2004 Dec 15.

Induced expression of rd29B, promotion of stomatal closure, and reduction in drought severity were observed in the abi1-1 mutant, which has a defect in the phosphatase ABI1, after HrpN was applied.
1(0,0,0,1) Details
16998070 Miao Y, Lv D, Wang P, Wang XC, Chen J, Miao C, Song CP: An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Plant Cell. 2006 Oct;18(10):2749-66. Epub 2006 Sep 22.

ATGPX3 physically interacted with the 2C-type protein phosphatase ABA INSENSITIVE2 (ABI2) and, to a lesser extent, with ABI1.
1(0,0,0,1) Details